Secondary breast angiosarcoma and paclitaxel-dependent prolonged disease control: report of two cases and review of the literature

Tumori
Donatella GambiniMaurizio Tomirotti

Abstract

Secondary breast angiosarcomas are a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. We report two cases of secondary breast angiosarcoma, both characterized by a very peculiar behavior towards paclitaxel. Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. When a locoregional recurrence was observed as a result of a brief treatment interruption or a treatment delay, a new complete remission was rapidly achieved with the resumption of the drug, without evidence of any significant adverse effects.

References

Apr 21, 2005·The British Journal of Dermatology·M YamadaK Takehara
Jun 11, 2005·Cancer·Keith M Skubitz, Philip A Haddad
Feb 14, 2006·The Breast : Official Journal of the European Society of Mastology·Max S ManoPeter Canney
Feb 16, 2006·Actas dermo-sifiliográficas·Laura PeramiquelAgustín Alomar
May 9, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rikiya NakamuraMasaru Miyazaki
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicolas PenelJean-Yves Blay
Oct 22, 2008·Nature Clinical Practice. Oncology·Rachel Abbott, Carlo Palmieri
Feb 25, 2009·Acta Oncologica·Elisabeth Perez-RuizAntonia Marquez
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Eriksson
Apr 6, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S StacchiottiP G Casali
Jan 31, 2012·The Oncologist·Isabelle Ray-CoquardUNKNOWN French Sarcoma Group (GSF/GETO)
Feb 7, 2012·The Breast : Official Journal of the European Society of Mastology·Aaron HuiAnita Skandarajah
Jun 20, 2012·Archives of Dermatology·Sachiko OnoYumi Matsumura
Sep 26, 2012·Archives of Gynecology and Obstetrics·G Hoffmann, I Mylonas
Oct 16, 2012·Clinical Breast Cancer·Antonio ToescaAlberto Luini
Oct 23, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Johannes MoesBastiaan Nuijen
Feb 8, 2013·Angiogenesis·Guido BocciRomano Danesi
Jan 5, 2014·Experimental Cell Research·Amalia AzzaritiMichele Guida

❮ Previous
Next ❯

Citations

Nov 12, 2016·The International Journal of Biological Markers·Antonio FloritaGiulio Zuanetti
Sep 6, 2020·American Journal of Clinical Oncology·Paulina M GutkinKathleen C Horst

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
W H Mattheiem, G Andry
© 2022 Meta ULC. All rights reserved