Secondary causes of nonalcoholic fatty liver disease.

Therapeutic Advances in Gastroenterology
Jacob M KneemanKathleen E Corey

Abstract

Nonalcoholic fatty liver disease (NAFLD) is becoming the most common cause of chronic liver disease in the developing world, found in 17-30% of the population in Western countries and 2-4% worldwide. Defined as the accumulation of fatty acid content greater than 5% of liver weight, NAFLD is a spectrum of disease ranging from simple steatosis to nonalcoholic steatohepatitis. The pathophysiology of NAFLD involves increased de novo synthesis of fatty acids in hepatocytes, the retention of lipids due to impaired hepatocyte apolipoprotein secretion or beta-oxidation. The well-known primary causes of NAFLD are obesity, type II diabetes, dyslipidemia, and insulin resistance. However, other less common conditions can cause a similar clinical and histologic picture, and should be considered in patients who present with NAFLD but do not have traditional risk factors. In this review, we discuss uncommon but important causes of NAFLD, including inborn errors of metabolism, iatrogenic causes, viral hepatitis, and nutritional disorders to provide practicing clinicians with an understanding of the less well recognized causes of NAFLD.

References

Jul 1, 1989·The Medical Clinics of North America·J H Lewis, H J Zimmerman
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B GuiguiE S Zafrani
Apr 12, 2001·Seminars in Liver Disease·J M WassermanS H Sigal
Feb 7, 2002·Lancet·Maurizio MuracaAlberto B Burlina
Feb 20, 2002·Journal of Gastroenterology and Hepatology·G LangmanG Todd
Oct 31, 2002·Best Practice & Research. Clinical Gastroenterology·Johane P Allard
Jun 24, 2003·The Journal of Laboratory and Clinical Medicine·Fabio FarinatiGiacomo Carlo Sturniolo
Aug 22, 2003·Pediatric Research·Barbara BurwinkelManfred W Kilimann
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ayman AbdoMark Swain
Jun 5, 2004·The American Journal of Medicine·Tjerk W A de BruinMarleen M J van Greevenbroek
Dec 16, 2005·The American Journal of the Medical Sciences·Brent A Neuschwander-Tetri
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jonas F LudvigssonScott M Montgomery
Apr 4, 2007·Alimentary Pharmacology & Therapeutics·P Angulo
Jul 20, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sandro MuntoniGerd Assmann
Jul 20, 2007·Journal of Hepatology·Srinevas K ReddyBryan M Clary
May 1, 1949·The American Journal of Medicine·R J KENNEDY, L R MURPHY
Sep 17, 2008·Dermatologic Clinics·Pedro HerranzMatias Mayor
Feb 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy Crum-CianfloneCharles Hames
Jun 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Noboru HaradaYoshihiko Maehara
Oct 13, 2009·Clinics in Liver Disease·Anjana A Pillai, Mary E Rinella
May 25, 2010·Journal of Hepatology·Vlad RatziuGiulio Marchesini
Jul 16, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Priya S KishnaniUNKNOWN ACMG
Sep 21, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jennifer C Price, Chloe L Thio
Oct 6, 2010·The American Journal of Medicine·Melvyn RubenfireRobert S Rosenson
Mar 8, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jason L BurkheadSvetlana Lutsenko
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arun J SanyalArthur McCullough
Apr 30, 2011·Clinical Medicine : Journal of the Royal College of Physicians of London·Christopher P Day

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Citations

Dec 25, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Salvatore PettaUNKNOWN Special Interest Group on Personalised Hepatology of Italian Association for Study of Liver AISF
Sep 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ling YangEkihiro Seki
Sep 9, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Jonathan G Stine, Naga Chalasani
Feb 18, 2016·The Journal of Pathology·Frances L Byrne, Kyle L Hoehn
May 2, 2015·Biochemical and Biophysical Research Communications·Wudelehu WuKatsumi Iizuka
Sep 7, 2016·BMC Medical Genetics·Rohini MehtaZobair Younossi
Jan 30, 2014·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Fábio da Veiga Ued, Virgínia Resende S Weffort
Jun 15, 2017·Expert Review of Gastroenterology & Hepatology·Hassan H A-Kader
Nov 2, 2017·Journal of Medicinal Food·A-Rang ImKwang Hoon Song
May 29, 2018·Journal of Digestive Diseases·Aida Ortega-Alonso, Raúl J Andrade
Nov 18, 2018·Molecular Nutrition & Food Research·Jerad H DumoltTodd C Rideout
Jun 22, 2018·Journal of Complementary & Integrative Medicine·Busisani W LembedeEliton Chivandi
Apr 24, 2019·International Journal of Molecular Sciences·Simona MarchiselloAgata Maria Rabuazzo
Jul 15, 2015·World Journal of Hepatology·Sara AshtariMohamad Reza Zali
Jun 22, 2019·Proceedings of the National Academy of Sciences of the United States of America·Guoqiang HuaPierre Chambon
Dec 17, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Michelle KozenieckiBrittney Patterson
Oct 12, 2019·Archives of Pathology & Laboratory Medicine·Mohamed MostafaChristopher P Hartley
Feb 15, 2019·Digestive Diseases and Sciences·Hannes HagströmAnna Andreasson
Feb 23, 2020·The Journal of Biological Chemistry·Fawzi AlogailiDavid Y Hui
Jan 4, 2020·European Journal of Pediatrics·Engy A MogahedMona S El-Raziky
Apr 16, 2020·Journal of Developmental Origins of Health and Disease·Jerad H DumoltTodd C Rideout
Oct 17, 2018·European Journal of Clinical Nutrition·Anja Bosy-WestphalManfred J Müller
Aug 14, 2019·Annals of Clinical and Translational Neurology·Marc-Olivier DeguiseRashmi Kothary
Jun 19, 2016·The Journal of Biological Chemistry·Allyson N HamlinDavid Y Hui
Aug 10, 2018·Toxicology Research·James E KlaunigZemin Wang
Sep 14, 2018·Canadian Journal of Gastroenterology & Hepatology·Sanda MustapicIvica Grgurevic
Jun 18, 2020·ACG Case Reports Journal·Layth MahdiHugo E Vargas

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Methods Mentioned

BETA
biopsy
gastric bypass
biopsies

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