PMID: 6972537Apr 1, 1981Paper

Secondary cytolytic T lymphocyte stimulation by purified H-2Kk in liposomes

Proceedings of the National Academy of Sciences of the United States of America
S H Herrmann, M F Mescher

Abstract

Purified H-2Kk incorporated into lipid vesicles induced a secondary allogeneic cytolytic T lymphocyte response. However, the level of the response was much less than that generated by using purified plasma membranes containing an equivalent amount of antigen. Similarly, reconstituted membranes stimulated less effectively than did intact plasma membranes. In both cases the stimulating activity of the antigen was increased by including a detergent-insoluble membrane matrix fraction during formation of the liposomes or reconstructed vesicles. Liposomes formed in the presence of the matrix were larger, were more irregular in shape, and had a higher density than those formed in its absence. Both the H-2 antigen and matrix proteins were incorporated into the same vesicles. The greater antigenicity of H-2 in vesicles containing the matrix protein might be due to either the larger size of the liposomes or interaction of the antigen with a component(s) of the matrix.

References

Dec 1, 1978·The Journal of Experimental Medicine·R FinbergS J Burakoff
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D R LittmanB D Schwartz
Mar 1, 1978·The Journal of Experimental Medicine·M MescherS Burakoff
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V H EngelhardS Burakoff
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N HollanderJ P Kriss
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V H EngelhardJ L Strominger
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S J BurakoffB Benacerrah
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·O WeinbergerS J Burakoff

❮ Previous
Next ❯

Citations

Jan 1, 1983·Pharmacology & Therapeutics·W E Magee, S S Ristow
Jan 1, 1992·Progress in Lipid Research·T Sato, J Sunamoto
Apr 5, 1983·Biochimica Et Biophysica Acta·Y I Henis, O Gutman
Jun 12, 1986·Biochimica Et Biophysica Acta·H M McConnellA A Brian
Feb 3, 1998·Journal of Immunological Methods·J CurtsingerM F Mescher
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G S CartwrightH M McConnell
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A A Brian, H M McConnell
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T H WattsH M McConnell
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Dal PortoJ P Schneck
Aug 10, 2010·The Cancer Journal·Cameron J Turtle, Stanley R Riddell
Nov 1, 1984·Cellular Immunology·K C StallcupM F Mescher
Sep 11, 1984·Biochemistry·J D CardozaM F Mescher
Jan 1, 1983·Immunological Reviews·G Berke
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·S H Herrmann, M F Mescher
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·S P Balk, M F Mescher
Jan 1, 1984·Cancer Immunology, Immunotherapy : CII·S J LeGrue
Dec 19, 2020·Biomaterials·Ariel IsserJonathan P Schneck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved