PMID: 7035536Jan 1, 1981Paper

Secondary dystrophies of corneal endothelium and Descemet's membrane: histological and ultrastructural study (author's transl)

Journal français d'ophtalmologie
G RenardY Pouliquen

Abstract

Secondary alterations in Descemet's membrance were noted in corneal specimens from 20 patients undergoing transfixing keratoplasty, after examination by optical, and in some cases, by transmission or scanning electron microscopy. The most frequent anomaly, thickening of Descemet's membrance, was observed in cases of prolonged or recurrent corneal affections, particularly interstitial keratitis, advanced forms of keratoconus, cicatricial leukomas, and keratoconus. Thickening was due to juxtaposition, with a normal Descemet's membrance, of repair tissue made up of collagen interspersed with zones of cell necrosis and isolated fibrils. These different layers could be interpreted as successive deposits of reparative endothelial cells, the ultrastructural appearance of each layer being characteristic of the type of cell from which it was derived. In this way, the history of each cornea can be reconstituted, from the original normal endothelial cell to the final endothelial repair cells, passing through all the intermediary types of fibroblastic cells. This relationship between the cells which manufacture descemetic tissue and the structure of Descemet's membrance is particularly evident in Groenouw's macular dystrophy type II in whi...Continue Reading

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