Secondary Echinococcus multilocularis infection in A/J mice: delayed metacestode development is associated with Th1 cytokine production

Parasite Immunology
I EmeryC Leclerc

Abstract

The course of Echinococcus multilocularis infection was studied in four different strains of mice after intrahepatic inoculation of a metacestode homogenate. Among these strains of mice, A/J and BALB/c mice were characterized, respectively, as the most resistant and susceptible strains. Although there was no significant difference between the mean surface of hepatic metacestodes of these two strains of mice at any examination time, 13 weeks after infection, the mean metastatic burden of A/J mice was significantly lower than that of BALB/c mice. Moreover, at this time, some BALB/c mice spontaneously died from their infection whereas all A/J mice remained in good health. The relative resistance of A/J mice to parasite development was associated with a strong and sustained in vitro spleen cell proliferative response to a crude E. multilocularis extract as well as with a high parasite-induced production of IFN-gamma and IL-2. The susceptibility of BALB/c mice was on the contrary associated with a high IL-4 production. Interestingly, the parasite extract also stimulated a significant IL-4 production by spleen cells of uninfected susceptible BALB/c mice, but not by control A/J mouse spleen cells. Altogether, these results suggest tha...Continue Reading

Citations

Mar 28, 2003·Transplantation·Stéphane KochUNKNOWN European Collaborating Clinicians
Jan 15, 2003·Clinical Microbiology Reviews·Wenbao ZhangDonald P McManus
Jul 18, 2006·Trends in Parasitology·Michael T RoganPhilip S Craig
Jun 23, 2016·International Journal for Parasitology. Parasites and Wildlife·Ian David WoolseyChristian Moliin Outzen Kapel
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Bresson-HadniJ P Miguet
Jan 14, 2000·The Korean Journal of Parasitology·J K ChoS W Cho
Jun 19, 2021·Acta Parasitologica·Chuanchuan LiuRi-Li Ge
Jul 15, 2021·Parasites & Vectors·Chuanchuan LiuLan Ma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.