Secondary Enucleations for Uveal Melanoma: A 7-Year Retrospective Analysis

American Journal of Ophthalmology
Ido Didi FabianVictoria M L Cohen

Abstract

To describe the indications for secondary enucleations in uveal melanoma and analyze associations and outcomes. Retrospective interventional case series. Data of patients who underwent secondary enucleation for uveal melanoma in the London Ocular Oncology Service, between 2008 and 2014, were retrieved from medical records analyzed. Cox regression model was performed to analyze associations with secondary enucleation and metastases and Kaplan-Meier estimates to assess the probability of metastatic spread and death. During the study period 515 enucleations were performed for uveal melanoma, 99 (19%) of which were secondary enucleations. Tumors were located at the ciliary body in 21 eyes (21%), juxtapapillary in 31 (31%), and choroid elsewhere in 47 (48%). Primary treatment included Ru(106) plaque radiotherapy, proton beam radiotherapy, and transpupillary thermotherapy in 85, 11, and 3 eyes, respectively. Indications for secondary enucleation were tumor recurrence in 60 (61%), neovascular glaucoma in 21 (21%), and tumor nonresponse in 18 eyes (18%). Twenty patients (20%) were diagnosed with metastasis and 12 out of 20 died of metastatic spread. On multivariate analysis, juxtapapillary tumor location was found to associate with tum...Continue Reading

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Citations

Mar 5, 2016·American Journal of Ophthalmology·Elsa BensoussanJean-Pierre Caujolle
Aug 17, 2017·Orbit·Chau M PhamSteven M Couch
Apr 11, 2018·Acta Ophthalmologica·Charlotte S E HogeboomAnnette C Moll
Jul 20, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aline I RiechardtAntonia M Joussen
Nov 10, 2017·Oman Journal of Ophthalmology·Bikramjit P PalVikas Khetan
Sep 13, 2020·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·P ZahorjanováM Štubňa

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