PMID: 1201528Nov 1, 1975Paper

Secondary epileptogenesis in frog forebrain: effect of inhibition of protein synthesis

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
F MorrellW H Harrison

Abstract

Secondary epileptogenesis was induced in the hippocampal cortex of the paralyzed bullfrog by means of localized, unilateral, intermittent electrical stimulation (kindling). Stimuli were designed to yield a brief but definite after-discharge. In control animals a progressive increase in after-discharge duration occurred at the 1 degree (stimulated) site and then at the 2 degrees site (contralateral hippocampus). Spontaneous epileptiform potentials (SEP's) occurred between stimuli, eventually independently on both sides. Cycloheximide (50 mg/kg) caused 88-99% reduction in protein synthesis, measured by 14C-leucine incorporation into brain protein. Cycloheximide-treated animals revealed no evidence of progressive prolongation of after-discharge duration when subjected to the kindling procedure (p = 0.1205 X 10(-7)). SEP's were reduced in the cycloheximide-treated animals, and confined to 1 degree hemisphere (p = 0.6 X 10(-10)). Since cycloheximide did not disturb normal electrogenesis or disrupt the after-discharges, this experiment distinguishes processes dependent upon electrical events from those requiring macromolecular synthesis. Protein synthesis seems critical to the emergence of spontaneous and autonomous epileptiform beha...Continue Reading

References

Jan 1, 1975·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·L B FlexnerR H Goodman
Sep 1, 1974·Behavioral Biology·G L WilcoxM W Luttges
May 1, 1974·Behavioral Biology·J P PinelG Deol
Nov 1, 1972·Experimental Neurology·K H Tress, L J Herberg
Apr 2, 1973·Biochemical and Biophysical Research Communications·J L Farber, R Farmar
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Aug 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·L B FlexnerR B Roberts
Nov 1, 1967·Neurology·B J Wilder, F Morrell
Dec 1, 1967·Neurology·B J Wilder, F Morrell
Aug 1, 1961·Neurology·F MORRELL, L BAKER
Jun 1, 1964·Epilepsia·R GUERRERO-FIGUEROAG GONZALEZ
Aug 1, 1965·Neurology·F MORRELLD A PRINCE
Aug 1, 1959·Archives of Neurology·F MORRELL
Jun 1, 1960·Epilepsia·F MORRELL

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Citations

Jan 1, 1985·Annals of the New York Academy of Sciences·L de Toledo-Morrell, F Morrell
Mar 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·L deToledo-Morrell, A M Kanner
Apr 7, 2017·Journal of Veterinary Internal Medicine·S KitzA Pakozdy
Jul 1, 2005·Epilepsia·João Pereira LeiteJorge Eduardo Moreira
Apr 24, 1986·Neuroscience Letters·M E MonetaE Jaimovich
Dec 1, 1979·Experimental Neurology·V Jonec, C G Walsterlain

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