PMID: 602929Jan 1, 1977Paper

Secondary gout in hemoglobinopathies: report of two cases and review of the literature

American Journal of Hematology
S P BallouJ W Harris

Abstract

Although patients with hemolytic hemoglobinopathies characteristically are over-producers of urate, and hyperuricemia is frequently recognized, clinical gout has rarely been reported in such patients. Our evaluation of 2 premenopausal women with gout led to the diagnosis of previously unrecognized hemoglobinopathies (SC disease and CC disease). Investigation of these 2 patients and review of the reported cases of gout in patients with hemoglobin S or C disorders suggest that relatively minor abnormalities of renal function in these patients may lead to early development of significant hyperuricemia. With increasing lifespan of patients with hemolytic hemoglobinopathies and the likelihood of increased occurrence of renal function abnormalities, it is anticipated that gout will more frequently be responsible for joint symptoms in such patients.

References

Dec 1, 1975·The American Journal of Medicine·H S DiamondA Cacatian
Nov 1, 1975·Arthritis and Rheumatism·T H Steele
Nov 1, 1975·Arthritis and Rheumatism·H S Diamond, A D Meisel
Mar 2, 1972·The New England Journal of Medicine·A Rastegar, S O Thier
Feb 1, 1973·Annals of Internal Medicine·H R SchumacherG McLaughlin
May 3, 1973·The New England Journal of Medicine·S Kilby-Kelberg
May 3, 1973·The New England Journal of Medicine
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Jan 1, 1974·Advances in Experimental Medicine and Biology·H DiamondA Cacatian
Jul 1, 1974·Medicine·L R EspinozaC K Osterland
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May 27, 1971·The New England Journal of Medicine·T H Steele
Jan 1, 1955·The American Journal of Medicine·W H CROSBY
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Feb 1, 1957·Annals of Internal Medicine·J W RANSONE, R D LANGE

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Citations

Apr 1, 1981·Annals of the Rheumatic Diseases·S P Ballou
May 1, 1983·Seminars in Arthritis and Rheumatism·D A Isenberg, Y Shoenfeld
Dec 1, 1980·Biochemical Medicine·C Bhuvaneswaran, M A Brewster
Oct 18, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Vijayalakshmi Kumar, Barry Gruber

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