Secondary hyperparathyroidism downregulates lipoprotein lipase expression in chronic renal failure

The American Journal of Physiology
N D VaziriK Liang

Abstract

In a recent study, we found marked downregulation of lipoprotein lipase (LPL) gene expression in fat, myocardium, and skeletal muscle of rats with chronic renal failure (CRF). Recently, hepatic lipase expression was shown to be depressed in CRF rats, and parathyroidectomy (PTX) was shown to reverse this abnormality. This study was undertaken to determine whether down-regulation of LPL expression in CRF is due to secondary hyperparathyroidism. Accordingly, LPL mRNA (Northern analysis), protein mass (Western analysis using mouse antibovine LPL monoclonal antibody, 5D2), and catalytic activity of the fat pad and soleus muscle were compared in five-sixths-nephrectomized male rats (CRF), parathyroidectomized CRF rats, and sham-operated control animals. The CRF animals exhibited marked hypertriglyceridemia and significant reductions of fat and skeletal muscle LPL mRNA abundance, protein mass, and catalytic activity (P < 0.05 vs. controls, for all parameters). PTX completely normalized the LPL mRNA, protein mass, and enzymatic activity and partially ameliorated the CRF hypertriglyceridemia (P < 0.05 vs. CRF group, for all parameters). Thus secondary hyperparathyroidism is responsible for impaired LPL expression in experimental CRF. Th...Continue Reading

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Citations

Mar 11, 2006·American Journal of Physiology. Renal Physiology·Gregory R Adams, Nosratola D Vaziri
Oct 20, 2011·Clinical and Experimental Nephrology·Nosratola D VaziriKeith C Norris
May 25, 2012·American Journal of Physiology. Renal Physiology·Shenyang LiDidier Portilla
Nov 23, 2019·Nutrients·Anna Gluba-BrzozkaJacek Rysz
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Kaihui Liang, N D Vaziri
Mar 11, 2004·American Journal of Physiology. Renal Physiology·N D VaziriK Liang
Mar 24, 2010·Nature Reviews. Nephrology·Nosratola D VaziriAlan M Fogelman
Jul 29, 2004·American Journal of Physiology. Renal Physiology·N D Vaziri, K Liang
Jan 13, 2006·American Journal of Physiology. Renal Physiology·N D Vaziri
Oct 26, 2012·Journal of Atherosclerosis and Thrombosis·William F KeaneDavid R Neff
May 20, 2021·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Clara ViñalsEmilio Ortega
Feb 9, 2005·Kidney International·Choong Kim, Nosratola D Vaziri
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Nosratola D Vaziri

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