Secondary Hyperparathyroidism in Heart Failure

The American Journal of the Medical Sciences
Mohamed S MorsyKarl T Weber

Abstract

Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Ca2+ and Mg2+ wasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Ca2+ overloading of myocytes and vascular smooth muscle with the induction of oxidative stress. Herein, we briefly review the presence and adverse outcomes of SHPT in persons with heart failure.

Citations

Jul 2, 2019·Circulation·Jack RychikUNKNOWN American Heart Association Council on Cardiovascular Disease in the Young and Council on Cardiovascular and Stroke Nursing
Feb 3, 2018·European Journal of Clinical Investigation·José Alberto Navarro-GarcíaGema Ruiz-Hurtado
Feb 7, 2021·The Journal of Biological Chemistry·Kaveh RayaniGlen F Tibbits
Feb 3, 2021·Micromachines·Leslie DonoghuePalaniappan Sethu
Nov 24, 2021·Current Opinion in Anaesthesiology·Catherine S ReidMatthias Siepe

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