Apr 1, 1976

Secondary IgG responses to type III pneumococcal polysaccharide. II. Different cellular requirements for induction and elicitation

The Journal of Immunology : Official Journal of the American Association of Immunologists
H Braley-Mullen

Abstract

Mice primed with a thymus- (T) dependent form of Type III pneumococcal polysaccharide (S3), i.e., S3 coupled to erythrocytes (S3-RBC) produce S3-specific IgG antibody after secondary challenge with either S3 or S3-RBC. The production of IgG antibody by mice challenged with S3 was shown to be T independent since secondary responses were enhanced when mice were treated with anti-lymphocyte serum (ALS) at the time of secondary challenge with S3 and T-depleted spleen cells responded as well as unfractionated spleen cells to S3 in an adoptive transfer system. Secondary S3-specific IgG responses in mice challenged with S3-RBC were shown to be T dependent by the same criteria. The results obtained by using S3 as the antigen indicate that IgG-producing B cells (B lambda cells) can recognize and respond to antigen in the absence of helper T cells. On the other hand, T cells were required for the induction of S3-specific memory B lambda cells since mice depleted of T cells by treatment with ALS at the time of priming with S3-RBC failed to produce S3-specific IgG antibody after secondary challenge with either S3-specific IgG antibody after secondary chall-nge with either S3 or S3rbc. Since RBC-specific memory cells were induced in T-depri...Continue Reading

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Mentioned in this Paper

T-Lymphocyte
Serum Sickness
Mice, Inbred BALB C
Spleen
Neoplasm of Uncertain or Unknown Behavior of Thymus
Disease of Thymus Gland
Thymic Tissue
Polysaccharides, Bacterial
Antibody Formation
B-Lymphocytes

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