Secondary KIT mutations: the GIST of drug resistance and sensitivity

British Journal of Cancer
Andrea Napolitano, Bruno Vincenzi

Abstract

Pharmacological targeting of KIT in gastrointestinal stromal tumours has dramatically changed the clinical outcome of this disease. Tyrosine kinase inhibitors are the cornerstone of this improvement, but resistance occurs through secondary KIT mutations. Studies aimed at improving our understanding of the molecular basis of sensitivity and resistance will soon allow us to further tailor our therapeutic strategies.

References

Oct 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichGeorge D Demetri
Apr 1, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo G CasaliUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group, Italian Sarcoma Group, and Au
Sep 6, 2018·Therapeutic Advances in Medical Oncology·Bruno VincenziMaria Abbondanza Pantaleo

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Citations

May 12, 2020·Frontiers in Oncology·Annalisa AstolfiMaria Abbondanza Pantaleo
Oct 14, 2020·EMBO Molecular Medicine·Thomas Gp GrünewaldDominique Heymann

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NCT02164240
NCT03465722
NCT03673501

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