Secondary metabolism in fungi: does chromosomal location matter?

Current Opinion in Microbiology
Jonathan M Palmer, Nancy P Keller

Abstract

Filamentous fungi produce a vast array of small molecules called secondary metabolites, which include toxins as well as antibiotics. Coregulated gene clusters are the hallmark of fungal secondary metabolism, and there is a growing body of evidence that suggests regulation is at least, in part, epigenetic. Chromatin-level control is involved in several silencing phenomena observed in fungi including mating type switching, telomere position effect (TPE), silencing of ribosomal DNA, regulation of genes involved in nutrient acquisition, and as presented here, secondary metabolite cluster expression. These phenomena are tied together by the underlying theme of chromosomal location, often near centromeres and telomeres, where facultative heterochromatin plays a role in transcription. Secondary metabolite gene clusters are often located subtelomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA, and HepA mediate cluster regulation.

References

Mar 1, 1997·Applied and Environmental Microbiology·S H LiangJ E Linz
Feb 3, 1999·Annual Review of Genetics·J E Haber
May 6, 1999·The EMBO Journal·F E Pryde, E J Louis
Aug 11, 2001·Science·T Jenuwein, C D Allis
Jan 5, 2002·Applied and Environmental Microbiology·Ching-Hsun ChiouJohn E Linz
Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Ana M CalvoNancy P Keller
Feb 18, 2004·Molecular Cell·Michael FreitagEric U Selker
Apr 13, 2004·Eukaryotic Cell·Jin Woo Bok, Nancy P Keller
Feb 3, 2005·Molecular Microbiology·Irene CastañoBrendan P Cormack
Jul 6, 2005·Current Opinion in Microbiology·Rupinder KaurBrendan P Cormack
Aug 5, 2005·Annual Review of Phytopathology·Jae-Hyuk Yu, Nancy Keller
Sep 10, 2005·Eukaryotic Cell·Jin Woo BokNancy P Keller
Sep 14, 2006·Molecular Microbiology·Jin Woo BokNancy P Keller
Mar 29, 2007·Natural Product Reports·Dirk Hoffmeister, Nancy P Keller
Apr 17, 2007·PLoS Pathogens·Robyn M PerrinNancy P Keller
Jul 10, 2007·Eukaryotic Cell·E Keats ShwabNancy P Keller
Oct 16, 2007·Molecular Cell·Patrick Trojer, Danny Reinberg
May 16, 2008·Organic & Biomolecular Chemistry·Russell B WilliamsRobert H Cichewicz
Aug 1, 2008·Fungal Genetics and Biology : FG & B·Shubha P KaleJin Woo Bok
Sep 13, 2008·PLoS Pathogens·Andrew McDonaghElaine Bignell
Oct 14, 2008·Eukaryotic Cell·Jonathan M PalmerNancy P Keller
Nov 1, 2008·Current Opinion in Microbiology·Ellen M Fox, Barbara J Howlett
Nov 18, 2008·Fungal Genetics and Biology : FG & B·D Ryan Georgianna, Gary A Payne
Dec 6, 2008·PloS One·J Greg DohenyThomas A Grigliatti
May 19, 2009·Nature Chemical Biology·Jin Woo BokNancy P Keller
Jun 13, 2009·Journal of Industrial Microbiology & Biotechnology·K M FischR H Cichewicz

❮ Previous
Next ❯

Citations

May 27, 2011·Applied Microbiology and Biotechnology·Ludmila V RozeJohn E Linz
Jul 21, 2012·Applied Microbiology and Biotechnology·Agnieszka Gacek, Joseph Strauss
Oct 3, 2013·Applied Microbiology and Biotechnology·Ulrich Kück, Julia Böhm
Jul 1, 2011·The Journal of Microbiology·Wenbing Yin, Nancy P Keller
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ben FieldAnne E Osbourn
May 24, 2013·Genome Biology and Evolution·Luke M Noble, Alex Andrianopoulos
May 21, 2013·Genome Research·Ronnie de JongeBart P H J Thomma
Apr 12, 2012·Applied and Environmental Microbiology·Lena StudtBettina Tudzynski
Jul 18, 2012·Molecular and Cellular Biology·Motoyuki ShimizuNaoki Takaya
Feb 26, 2013·BMC Genomics·Lea AtanasovaIrina S Druzhinina
Feb 6, 2014·PLoS Pathogens·Daniel H ScharfAxel A Brakhage
Oct 23, 2013·Journal of Industrial Microbiology & Biotechnology·Philipp Wiemann, Nancy P Keller
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mikael R AndersenUffe H Mortensen
Mar 4, 2014·Trends in Plant Science·Svetlana BoychevaTeresa B Fitzpatrick
Apr 26, 2011·Annual Review of Phytopathology·Saori Amaike, Nancy P Keller
Feb 10, 2012·Journal of Biomedicine & Biotechnology·Carlos BarreiroCarlos García-Estrada
Feb 6, 2014·Critical Reviews in Microbiology·Yvon WoappiOm V Singh
Jan 1, 2015·Pathogens·Yongming Sang, Frank Blecha
Dec 17, 2015·Applied Microbiology and Biotechnology·Juan F Martín, Paloma Liras
Dec 5, 2012·Fungal Genetics and Biology : FG & B·Pranav ChettriRosie E Bradshaw
Mar 31, 2012·Trends in Plant Science·Nathan De GeyterAlain Goossens
Feb 22, 2012·International Journal of Food Microbiology·Lara Munique FerracinMaria Helena Pelegrinelli Fungaro
Mar 23, 2011·Biotechnology Advances·Johannes F ImhoffJutta Wiese
Sep 3, 2010·Fungal Genetics and Biology : FG & B·Marko Rohlfs, Alice C L Churchill
Jul 11, 2014·Fungal Genetics and Biology : FG & B·Neil Andrew BrownGustavo Henrique Goldman
Sep 30, 2015·Fungal Genetics and Biology : FG & B·Scott GriffithsJérôme Collemare
Mar 2, 2013·The New Phytologist·Rosie E BradshawMurray P Cox

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.