Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa

Chemistry & Biodiversity
Li-Wen ChenIh-Sheng Chen

Abstract

Bioassay-guided fractionation of the active AcOEt-soluble layer led to the isolation of two new pyranocoumarins, 3-hydroxyxanthyletin (1) and 3-methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)-(S)-marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumisoflavone (9) genistein (10), 2'-hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)-naringenin (15); three benzenoids, i.e., 4-hydroxybenzaldehyde (16), vanillin (17), and (S)-lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6beta-hydroxystigmast-4-en-3-one (20) and 6beta-hydroxystigmasta-4,22-dien-3-one (21), and a mixture of beta-sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses. Among these isolates, 3-hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)-naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H(37)R(V) in vitro with MIC values of 16, 35, 30, and < or =2.8 microg/ml, re...Continue Reading

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Citations

May 23, 2012·The Journal of Infectious Diseases·Sahil MahajanPawan Gupta
Sep 29, 2011·International Journal of Molecular Sciences·Shao-Peng WeiZhi-Qin Ji
Jan 7, 2015·European Journal of Medicinal Chemistry·Weiyun ShenJinyan Dong
May 6, 2011·Journal of Natural Products·Ming-Chun WuIan-Lih Tsai
Nov 16, 2011·Chemistry & Biodiversity·Tsung-Hsien ChouIh-Sheng Chen
Jan 24, 2014·Beilstein Journal of Organic Chemistry·Alexander O Terent'evValery M Dembitsky
Sep 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bumjung KimKyungjin Lee
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhamad Harith MazlunZunoliza Abdullah
Sep 26, 2019·Frontiers in Pharmacology·Sylvin Benjamin AtebaDieudonné Njamen
Jan 26, 2021·Journal of Food Biochemistry·Siti Norhamimah Mohamed YunusFaridah Abas

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