Secondary metabolites from an algicolous Aspergillus versicolor strain.

Marine Drugs
Feng-Ping MiaoNai-Yun Ji

Abstract

Two new compounds, asperversin A (1) and 9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (9), ergosta-7,22-diene-3β,5α,6β-triol (10), and 6β-methoxyergosta-7,22-diene-3β,5α-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC₅₀ value of 0.5 μg/mL.

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Citations

May 28, 2013·Marine Biotechnology·Yoon Mi LeeJee H Jung
Jun 5, 2015·Marine Drugs·Lijian XuQinggui Wang
Aug 20, 2015·Marine Drugs·Natalie Netz, Till Opatz
Dec 25, 2015·Applied Microbiology and Biotechnology·P Akilandeswari, B V Pradeep
Mar 16, 2016·Journal of the American Chemical Society·Gustavo M Borrajo CallejaClément Mazet
Jul 17, 2012·Fitoterapia·Xiao-Dong LiNai-Yun Ji
Jan 27, 2015·Frontiers in Microbiology·Sunil K DeshmukhSarita V Bhave
Jan 1, 2015·Applied Microbiology and Biotechnology·Ravindra Pal SinghC R K Reddy
Jul 25, 2012·Organic Letters·Feng-Ping MiaoNai-Yun Ji
Dec 24, 2014·Marine Drugs·Ri-Ming HuangCheng-Hai Gao
Nov 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaohan WangLigang Zhou
Jul 11, 2018·Applied Microbiology and Biotechnology·Vera A VilValery M Dembitsky
Apr 16, 2015·Applied Microbiology and Biotechnology·Tzi Bun NgAlaa El-Din Bekhit
Jan 7, 2014·Natural Product Reports·John W BluntMichèle R Prinsep
Jul 12, 2017·Frontiers in Microbiology·Manik Prabhu Narsing RaoWen-Jun Li
Nov 18, 2020·Toxins·Marco Masi, Antonio Evidente
Nov 18, 2020·Journal of Fungi·Lan Lin, Jianping Xu
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valery M DembitskyVladimir V Poroikov
Mar 4, 2021·Organic Letters·Zhi Zhang, Liansuo Zu
Apr 20, 2021·Heliyon·Esraa Ahmed Mohamed El-BondklyAya Ahmed Mohamed El-Bondkly

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Methods Mentioned

BETA
NMR
column chromatography

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