Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae).

Natural Product Research
Roshamur Cahyan ForestraniaEsperanza Carcache de Blanco

Abstract

Two new glycerol esters, (S)-2-hydroxy-3-(octanoyloxy)propyl tetracosanoate (1) and (S)-3-(((S)-11-acetoxy octadecanoyl)oxy)propane-1,2-diyl diacetate (2), and eight known compounds, docosanedioic acid (3), 2,5-dimethylnonadecane (4), lupeol (5), stigmasterol (6), β-sitosterol (7), heptadecanoic acid (8), hexanedioic acid, 1,6-bis[(2R)-ethylhexyl] ester (9), and 1,3-di-O-[2',2'-di-(p-phenylene)] (10) were isolated from the leaves of Garcinia daedalanthera Pierre, collected from Indonesia. Structural analysis of the isolates was performed using 1 D- and 2 D-NMR, LC- and GC-MS, IR, polarimetry, and UV-visible spectroscopic methods. Cytotoxicity assessments, as well as reactive oxygen species (ROS) analysis of the isolates, were also completed. Lupeol was the only compound found active with an IC50 value of 19.2 µM against HT-29 colon cancer cells. Significant ROS inhibition and induction activity was observed for compounds 4 and 8, respectively.

References

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Aug 12, 2004·Chemical & Pharmaceutical Bulletin·Shu-Hua QiLi-Juan Long
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May 16, 2014·Pharmaceutical Biology·Bernadette Biloa MessiMuriel Cuendet
Jan 29, 2019·Anti-cancer Drugs·Gerardo D Anaya-EugenioEsperanza Carcache de Blanco

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Citations

Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Didi Nurhadi IllianMohammad Basyuni

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