PMID: 7523950Jul 1, 1994Paper

Secondary metabolites of Penicillium bilaii strain PB-50

Mycopathologia
M E SavardR A Samson

Abstract

A phosphate-solubilizing strain of Penicillium bilaii was tested for the production of gliotoxin and other toxic compounds. The strain was fermented under five different conditions to allow the expression of various metabolites, including gliotoxin. These included Czapek-yeast extract medium under both shaken and still conditions as well as Czapek-yeast extract/malt extract/peptone medium and sucrose/glycerol medium in shake flasks. In addition, culture filtrate from an industrial fermentation of the fungus was examined. No gliotoxin was produced in any of the media. No other expected P. bilaii metabolites were found. Three compounds were identified in all samples: dibutyl phthalate, 1-(4-hydroxy-phenyl)ethanone and 4-hydroxy-3,6-dimethyl-2H-pyran-2-one. The production of other metabolites was dependent on the culture conditions. Two hyalodendrin derivatives were found in some fermentations and two related compounds were tentatively identified. None of the compounds found have been reported as toxic. The identity of the culture was confirmed by comparison with the ex-type culture of P. bilaii.

References

Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A Müllbacher, R D Eichner

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Citations

Sep 17, 2009·Analytical and Bioanalytical Chemistry·Kristian Fog NielsenJens Christian Frisvad
Apr 25, 2007·Journal of Asian Natural Products Research·G ChenR-Q Zhang
Jul 12, 2018·Applied Microbiology and Biotechnology·Magnus Hallas-MøllerJens Christian Frisvad
Sep 25, 2004·Mass Spectrometry Reviews·Silas G Villas-BôasJens Nielsen
Mar 11, 2017·Natural Product Research·Hui WangQi Wang
Nov 18, 2018·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Huawei ZhangHong Wang
Jul 21, 2020·Critical Reviews in Biotechnology·Raj Narayan Roy

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