Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa.

The Journal of Antibiotics
Daiani Cristina SaviJürgen Rohr

Abstract

The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dioxolanone phenguignardic acid butyl ester (1a) had low phytotoxic activity in citrus leaves and fruits (at dose of 100 µg), and its importance as virulence factor in citrus black spot disease needs to be further addressed. Beside the phytotoxic analysis, we also evaluated the antibacterial (against methicillin sensitive and resistant Staphylococcus aureus) and cytotoxic (A549 non-small cell lung cancer, PC3 prostate cancer and HEL 299 normal epithelial lung) activities of the isolated compounds, which revealed that compounds 1a, 1b and 2a were responsible for the antibacterial activity of this strain.

References

Jul 12, 2012·Journal of Natural Products·Daniel MolitorEckhard Thines
Feb 15, 2013·Phytochemistry·Iris BuckelEckhard Thines
Mar 1, 2006·Mycobiology·In-Kyoung LeeBong-Sik Yun
Sep 15, 2016·Parasite : Journal De La Société Française De Parasitologie·Klaus TeichmannFranz Hadacek
Mar 3, 2018·Folia Microbiologica·Aliandra G de MedeirosChirlei Glienke

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Methods Mentioned

BETA
NMR

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