Secondary Ocular Hypertension and the Risk of Glaucoma Surgery After Dexamethasone Intravitreal Implant in Routine Clinical Practice

Ophthalmic Surgery, Lasers & Imaging Retina
Kornwipa HemaratJay M Stewart

Abstract

To determine the rate of ocular hypertension (OHT) after dexamethasone intravitreal implant in routine clinical practice and identify patient characteristics associated with a risk for glaucoma surgery. The charts of 260 eyes from 221 patients with diabetic macular edema, retinal vein occlusion, uveitis, and macular edema secondary to various causes treated with one or more dexamethasone implants were reviewed. Intraocular pressure (IOP), medications, and glaucoma interventions were collected before and after implantation. The mean baseline IOP was 14.3 mm Hg ± 3.6 mm Hg, and after receiving dexamethasone implant(s), 26.2% and 7.7% of patients had IOP greater than 25 mm Hg and 35 mm Hg, respectively. There was evidence (P < .001) of an association between preexisting glaucoma or glaucoma suspect status (103 eyes) and need for glaucoma surgery, and 4.62% (12 eyes) required glaucoma surgery. Secondary OHT induced by the dexamethasone implant can usually be controlled by medications, but the incidence of OHT requiring glaucoma surgery was high (4.62%) in our study relative to rates previously reported in the literature. All patients, especially those with preexisting glaucoma, should be advised of the possible need for glaucoma su...Continue Reading

References

Jan 12, 2011·Archives of Ophthalmology·Careen LowderUNKNOWN Ozurdex HURON Study Group
Mar 14, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Linda M Meyer, Carl-Ludwig Schönfeld
Apr 6, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K SchmitzUNKNOWN German Retinal Vein Occlusion Group
May 13, 2014·Journal français d'ophtalmologie·S GuigouF Meyer
Mar 31, 2015·Archivos de la Sociedad Española de Oftalmología·B Jiménez-GómezS Valsero Franco
Apr 16, 2016·European Journal of Ophthalmology·Frederic MatontiSebastien Guigou

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Citations

Jan 17, 2020·Taiwan Journal of Ophthalmology·Jorge Chawan-SaadLihteh Wu
Jul 21, 2021·Journal français d'ophtalmologie·N Guemes-VillahozJ Donate-López

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