Nov 5, 1977

Secondary pituitary hyperplasia in Addison's disease

R ClaytonF D Rosenthal


In patients with Addison's disease, whether treated or untreated for the previous 24 hours, hydrocortisone produced only a partial suppression of their elevated adrenocorticotrophic-hormone (A.C.T.H.) levels. This is comparable to untreated myxoedema, in which administration of triiodothyronine fails to inhibit secretion of thyrotrophin (T.S.H.). In myxoedema, however, continued treatment produces normal T.S.H. levels. Inadequate A.C.T.H. suppressibility in patients with Addison's disease while on treatment may be due to the maintenance of a secondary pituitary hyperplasia by inadequate replacement therapy. This may be clinically important, especially in the genesis of Nelson's syndrome.

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Mentioned in this Paper

Process of Secretion
Visual Suppression
Triiodothyronine Measurement
Pituitary-Adrenal System
Metabolic Suppression
Thyroid Stimulating Hormone Measurement
Cell Secretion

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