Secondary prevention of cardiogenic arterial thromboembolism in the cat: The double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT)

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
Daniel F HoganHsin-Yi Weng

Abstract

To determine if clopidogrel administration is associated with a reduced likelihood of recurrent cardiogenic arterial thromboembolism (CATE) in cats compared to aspirin administration. Secondary aims were to determine if clopidogrel administration had an effect on the composite endpoint of recurrent CATE and cardiac death and to identify adverse effects of chronic clopidogrel or aspirin therapy. Seventy-five cats that survived a CATE event. Multicenter, double-blind, randomized, positive-controlled study. Cats were assigned to clopidogrel (18.75 mg/cat PO q 24 h) or aspirin (81 mg/cat PO q 72 h). Kaplan-Meier survival curves were created for each endpoint and the log rank test performed to compare treatment groups with respect to time to event and the likelihood of the event occurring. The mean age of all cats was 8.0 ± 3.5 yr and 57/75 (76%) were male (p < 0.001); 62/75 (83%) were mixed breed with the remainder including Persian, Abyssinian, American Shorthair, Bengal, Birman, Himalayan, Maine Coon, Ragdoll, Snowshoe, and Sphynx breeds. Only 15% (11/75) of cats had a history of heart disease recorded prior to the CATE event. Clopidogrel administration was associated with significantly reduced likelihood of recurrent CATE compar...Continue Reading

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Citations

Mar 13, 2016·Journal of Veterinary Pharmacology and Therapeutics·J ThomasonA Mackin
Sep 7, 2016·Journal of Veterinary Emergency and Critical Care·Amy C Dixon-JimenezGregg S Rapoport
May 31, 2017·Journal of Veterinary Internal Medicine·M A OyamaP A Shaw
Apr 17, 2018·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kyle P VititoeRobert T O'Brien
Jun 20, 2018·Journal of Veterinary Pharmacology and Therapeutics·Marilyn N MartinezKatrina L Mealey
Sep 11, 2018·Veterinary Clinical Pathology·Signe E CremerLise N Nielsen
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Robert GoggsRonald H L Li
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Marie-Claude BlaisClaire R Sharp
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Benjamin M BrainardElizabeth A Rozanski
Sep 29, 2019·The Veterinary Record·Henrietta Fforde-LutterEmma Place
Jan 11, 2020·The Journal of Small Animal Practice·P GantK Humm
Apr 4, 2020·Journal of Veterinary Internal Medicine·Virginia Luis FuentesJoshua A Stern
Oct 7, 2020·Journal of the American Veterinary Medical Association·Shane D MurphyJune E Olds
Nov 27, 2020·Journal of Veterinary Internal Medicine·Samantha L KochieVedat Yildez
Jan 20, 2021·Journal of Veterinary Internal Medicine·Mackenzie RuehlJulien Guillaumin
May 11, 2021·Journal of Feline Medicine and Surgery·Sara T LoJoshua A Stern
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté
Apr 24, 2018·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Mark A OyamaSusan S Ellenberg

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