Secondary prevention strategy of cardiovascular disease using endothelial function testing

Circulation Journal : Official Journal of the Japanese Circulation Society
Yasushi MatsuzawaAmir Lerman

Abstract

Over the past decades, secondary prevention of cardiovascular (CV) disease has improved and considerably reduced mortality rates. However, there remains a high-rate of new or recurrent CV events in those with established atherosclerotic vascular diseases. Although most of the prevailing therapies target the conventional risk factors, there is notable interindividual heterogeneity in adaptation to risk factors and response to therapies, which affects efficacy. It is desirable to have a methodology for directly assessing the functional significance of atherogenesis, and for managing individual patients based on their comprehensive vascular health. Endothelial function plays a pivotal role in all stages of atherosclerosis, from initiation to atherothrombotic complication. Endothelial function reflects the integrated effect of all the atherogenic and atheroprotective factors present in an individual, and is therefore regarded as an index of active disease process and a significant risk factor for future CV events. Moreover, improvement in endothelial function is associated with decreased risk of CV events, even in the secondary prevention setting. The introduction of endothelial function assessment into clinical practice may trigge...Continue Reading

References

Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Apr 1, 1996·The American Journal of Physiology·I T MeredithM A Creager
May 20, 1998·Clinical Therapeutics·W B Kannel
Jan 14, 1999·The New England Journal of Medicine·R Ross
Aug 7, 2002·Circulation·Julian P J HalcoxArshed A Quyyumi
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Piero O BonettiAmir Lerman
Sep 19, 2003·Journal of the American College of Cardiology·Sammy Y ChanAndrew Ignaszewski
Mar 10, 2004·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Jul 14, 2004·Hypertension·Gary F MitchellEmelia J Benjamin
Dec 8, 2004·Journal of the American College of Cardiology·Piero O BonettiAmir Lerman
Jan 26, 2005·Circulation·Amir Lerman, Andreas M Zeiher
Mar 10, 2005·The New England Journal of Medicine·John C LaRosaUNKNOWN Treating to New Targets (TNT) Investigators
Sep 20, 2005·Journal of the American College of Cardiology·Matthias FrickFranz Weidinger
Apr 15, 2006·Journal of Applied Physiology·Anju NohriaPeter Ganz
May 5, 2006·Fundamental & Clinical Pharmacology·Robinson JoannidesChristian Thuillez
Oct 19, 2006·Coronary Artery Disease·Mikko I MäyränpääPetri T Kovanen
Nov 7, 2007·The New England Journal of Medicine·Philip J BarterUNKNOWN ILLUMINATE Investigators
Jan 9, 2008·International Journal of Cardiology·Marco GuazziRoss Arena
Jun 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Barry A BoilsonRobert D Simari
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Jan 24, 2009·Journal of the American College of Cardiology·Yoshinobu KittaKiyotaka Kugiyama
May 2, 2009·European Journal of Heart Failure·Michael ShechterDov Freimark
May 26, 2009·The American Journal of Cardiology·Andrew C PhilpottTodd J Anderson
Jul 29, 2009·Nature Reviews. Cardiology·Santiago Roura, Antoni Bayes-Genis
Apr 17, 2010·Journal of the American College of Cardiology·Yasushi MatsuzawaHisao Ogawa
Sep 4, 2010·Journal of the American College of Cardiology·Barry A BorlaugMargaret M Redfield
Dec 9, 2010·Circulation. Cardiovascular Quality and Outcomes·Tom G BriffaMatthew Knuiman
Mar 5, 2011·International Journal of Cardiology·Isao TakishimaKiyotaka Kugiyama

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Citations

Mar 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenya KusunoseMasataka Sata
Jul 28, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomoya YamashitaKen-Ichi Hirata
Sep 1, 2016·Journal of Clinical Lipidology·Michael MillerAndrew P Goldberg
Jun 24, 2017·Menopause : the Journal of the North American Menopause Society·Shilpa N Bhupathiraju, JoAnn E Manson
Jun 5, 2019·High Altitude Medicine & Biology·Mario GrittaniPlinio Cirillo
Jul 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Anthony S ZannasDavid R Rubinow
Aug 2, 2020·Clinical and Experimental Dental Research·Takahito FujitaniMasato Minabe
Jan 14, 2020·Critical Reviews in Food Science and Nutrition·Berner Andrée Sandoval-RamírezRosa Solà
Jul 3, 2021·Journal of Psychiatric Research·Aline J WaclawovskyFelipe B Schuch

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