Secondary structural changes of proteins in fingernails of chronic fatigue syndrome patients from Fourier-transform infrared spectra

Clinica Chimica Acta; International Journal of Clinical Chemistry
Akikazu SakudoKazuyoshi Ikuta

Abstract

Generally, nails can be an index of health, with abnormalities sometimes found under diseased conditions. Fatigue is also supposed to affect the condition of nails. Possible differences in infrared (IR) spectra of nail plates of chronic fatigue syndrome (CFS) patients compared to healthy control subjects were investigated in this study. Using an attenuated total reflection (ATR)-Fourier-transform infrared (FTIR) spectrophotometer, spectra in the region of 4000-600 cm(-1) were obtained. The amide I region was then separated by Fourier deconvolution and curve fitting based on the Gauss and Lorentz formula and revealed differences in the secondary structural content of proteins compared to healthy donors. The specific secondary structural pattern commonly observed in nails of male and female CFS patients in the absence and presence of medication indicated a decreased alpha-helix content and increased beta-sheet content, suggesting reduced levels of normal elements of the nail plate. This provides the first evidence of alterations in the fingernails of CFS patients which could be detected by IR spectroscopy. Possible explanations for the alterations will be discussed.

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Citations

Dec 1, 2010·Bulletin of Experimental Biology and Medicine·S A KhaustovaA G Tonevitsky
Nov 26, 2013·International Journal of Pharmaceutics·Nam Ah KimSeong Hoon Jeong
Feb 8, 2014·Drug Development and Industrial Pharmacy·Nam Ah KimSeong Hoon Jeong
Oct 2, 2015·The Journal of Investigative Dermatology·Adina CoroabaMariana Pinteala
Apr 24, 2012·International Journal of Pharmaceutics·Kenneth A WaltersMajella E Lane
Mar 3, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu SakudoKazuyoshi Ikuta
Jul 29, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nam Ah KimSeong Hoon Jeong
May 16, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu SakudoKazuyoshi Ikuta
Oct 25, 2016·International Journal of Pharmaceutics·Nam Ah KimSeong Hoon Jeong
Oct 30, 2016·International Journal of Cosmetic Science·P Thatai, B Sapra
Apr 20, 2016·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·Yechuan HuangAnlin Li
Sep 15, 2018·The British Journal of Dermatology·S De BruyneJ Delanghe
Dec 15, 2017·Critical Reviews in Clinical Laboratory Sciences·Sander De BruyneJoris R Delanghe
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca E ChiriacMariana Pinteala

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