PMID: 7024913Jul 24, 1981Paper

Secondary structure of the large subunit ribosomal RNA from Escherichia coli, Zea mays chloroplast, and human and mouse mitochondrial ribosomes

Nucleic Acids Research
C GlotzH Kössel

Abstract

Short base-paired RNA fragments, and fragments containing intra-RNA cross-links, were isolated from E. coli 23S rRNA or 50S ribosomal subunits by two-dimensional gel electrophoresis. The interactions thus found were used as a first basis for constructing a secondary structure model of the 23S rRNA. Sequence comparison with the 23S rDNA from Z. mays chloroplasts, as well as with the 16S (large subunit) rDNA from human and mouse mitochondria, enabled the experimental model to be improved and extrapolated to give complete secondary structures of all four species. The structures are organized in well-defined domains, with over 450 compensating base changes between the two 23S species. Some ribosomal structural "'switches" were found, one involving 5S rRNA.

References

Apr 15, 1976·European Journal of Biochemistry·J RinkeR Brimacombe
Aug 7, 1975·Nature·G E Fox, C R Woese
Oct 2, 1974·European Journal of Biochemistry·I Newton, R Brimacombe
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J BrosiusH F Noller
Jul 31, 1980·Nature·I C EperonD P Nierlich
Oct 6, 1980·FEBS Letters·R N Nazar

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Citations

Jan 1, 1987·Journal of Molecular Evolution·J L GorskiR D Schmickel
Oct 1, 1996·Journal of Molecular Evolution·M S Springer, E Douzery
Sep 20, 1991·Journal of Molecular Biology·A V MunishkinA B Chetverin
Jan 1, 1982·Progress in Biophysics and Molecular Biology·A Liljas
Jan 1, 1986·Progress in Biophysics and Molecular Biology·K Nagano, M Harel
Jan 1, 1988·Progress in Biophysics and Molecular Biology·H A RauéW Musters
Jul 20, 2002·Current Opinion in Structural Biology·Robin R GutellJamie J Cannone
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·V F de la CruzL Simpson
Oct 1, 1983·Journal of Biomolecular Structure & Dynamics·P H van Knippenberg, H A Heus
Apr 24, 1982·Nucleic Acids Research·W Traub, J L Sussman
Jan 25, 1983·Nucleic Acids Research·F Sor, H Fukuhara
Nov 25, 1983·Nucleic Acids Research·V C WareS A Gerbi
Feb 11, 1983·Nucleic Acids Research·M SilberklangV A Erdmann
Oct 25, 1984·Nucleic Acids Research·G Strittmatter, H Kössel
Apr 25, 1984·Nucleic Acids Research·A A HadjiolovL P Yavachev
Jun 11, 1985·Nucleic Acids Research·D O Clary, D R Wolstenholme
Jul 11, 1985·Nucleic Acids Research·P Spitnik-ElsonR Abramowitz

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