Secondary surfactant deficiency in neonates

Journal of Perinatology : Official Journal of the California Perinatal Association
Robin BissingerDorothea Eicher

Abstract

Surfactant treatment has become the standard of care in premature infants with respiratory distress syndrome (RDS). Pulmonary hemorrhage, pulmonary edema, pneumonia, and atelectasis have been shown to liberate inflammatory mediators and plasma proteins, which damage type II pneumocytes and inactivate surfactant. These disease processes may, therefore, lead to a secondary surfactant inactivation or deficiency, which can be an unrecognized cause of respiratory decompensation after initial recovery from RDS in this vulnerable population. This is a descriptive report of three cases, which had acute respiratory decompensation between 1 and 3 weeks of age. All three infants demonstrated a response to secondary doses of surfactant. We submit that the diagnosis and treatment of secondary surfactant deficiency in the critically ill premature neonate warrants further study.

References

Jan 1, 1994·Respiration; International Review of Thoracic Diseases·K Harms, E Herting
Aug 1, 1996·Critical Care Medicine·D F WillsonH Dalton
Jan 1, 1996·Intensive Care Medicine·M MorenoA Carrillo
May 18, 1999·Archives of Disease in Childhood·J López-HerceR Moral

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Citations

Nov 3, 2004·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S RiveraJ Messer
Oct 12, 2013·BMC Pediatrics·Emmanuel LopezUNKNOWN French Young Neonatologist Club
May 26, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·L A Katz, J M Klein
Feb 1, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·R BissingerD Jenkins
Feb 12, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·J D MerrillR A Ballard
May 23, 2007·European Journal of Pediatrics·Jasper V Been, Luc J I Zimmermann
Oct 27, 2015·The Journal of Pediatrics·Roberta A BallardUNKNOWN TOLSURF Study Group
Mar 23, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Narongsak NakwanCheep Charoenlap
Feb 20, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Theresa R GroverCarl W White
Apr 1, 2016·Indian Pediatrics·Bonny JasaniRuchi Nanavati
Aug 25, 2018·Pediatric Research·Philip L BallardUNKNOWN Tolsurf Investigators
Mar 20, 2021·The Indian Journal of Radiology & Imaging·Sanjay N JainRavi U Varma

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