PMID: 108473Feb 1, 1979

Secondary thrombocytopenia following phenobarbital treatments in a rhesus monkey (Macaca mulatta)

Laboratory Animal Science
P W FergusonR I Krieger

Abstract

A rare adverse reaction due to phenobarbital (10 mg/kg/day for 11 days) developed in a rhesus monkey (Macaca mulatta). Clinical signs and measured hematological parameters correlated closely with descriptions of thrombocytopenia. Following cessation of phenobarbital, the monkey recovered within 11 days. Five months after initial thrombocytopenia, the monkey was challenged again with phenobarbital (10 mg/kg/day for 11 days). Appearance and progression of clinical signs were identical to the initial crisis.

Related Concepts

Anthropoidea
Complete Blood Count
Blood Platelets
Macaca
Macaca mulatta
Monkey Diseases
Luminal
Thrombocytopenia

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