Secondary tics or tourettism associated with a brain tumor

Pediatric Neurology
Aimee F LuatHarry T Chugani

Abstract

Tourette syndrome is generally considered to be a genetic disorder, but symptoms mimicking Tourette syndrome can be secondary to an underlying lesion disrupting the basal ganglia circuitry. Described here is a case of secondary tics, or tourettism, in a child with a large oligodendroglioma of the right temporal lobe extending to the basal ganglia. He presented with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and stimulant-induced tic disorder at the age of 11 years, and later also had also seizures. The family history was unremarkable. Cranial magnetic resonance imaging disclosed a right temporal lobe tumor extending to the basal ganglia. An alpha-[(11)C]methyl-l-tryptophan positron emission tomography scan showed asymmetric uptake in the basal ganglia and intense uptake in the tumor. He had a lesionectomy, and the histopathologic diagnosis was oligodendroglioma. Neuropsychologic testing after surgery revealed no attention-deficit hyperactivity disorder symptomatology, and only minimal features of obsessive-compulsive disorder. The present case provides additional evidence supporting the role of basal ganglia circuitry in the pathophysiology of tic disorder and its comorbid states. Children who pres...Continue Reading

References

Aug 1, 1990·American Journal of Medical Genetics·D E Comings
Feb 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J F LeckmanD L Pauls
Dec 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A R BraunT N Chase
Jun 8, 2001·Paediatric Drugs·E H Kossoff, H S Singer
Oct 20, 2001·The New England Journal of Medicine·J Jankovic
Apr 16, 2003·Archives of General Psychiatry·Bradley S PetersonLawrence Staib
Feb 22, 2005·Lancet Neurology·Harvey S Singer
May 4, 2005·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Nicte I Mejia, Joseph Jankovic
Aug 5, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Csaba JuhászHarry T Chugani
Jun 20, 2006·Developmental Medicine and Child Neurology·Veit RoessnerAribert Rothenberger
Mar 6, 2007·Journal of the Neurological Sciences·Dustin Y YoonHarvey S Singer
Aug 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Michael BehenOtto Muzik
Sep 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Malek I MakkiHarry T Chugani

❮ Previous
Next ❯

Citations

Oct 16, 2012·The Clinical Neuropsychologist·Callie B DunnAparna A Wagle Shukla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Carolyn H Kwak, Joseph Jankovic
Alzheimer Disease and Associated Disorders
G E CooperR D Jones
© 2022 Meta ULC. All rights reserved