Secondary Tumors of the Gynecologic Tract: A Clinicopathologic Analysis

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Georgia KarpathiouMichel Peoc'h

Abstract

Although the spread of extragenital tumors to individual female genital tract organs, particularly the ovary, has been much studied, histologic data with regard to secondary tumors involving the whole gynecologic tract are largely lacking. Thus, the aim of the study was to investigate the pathologic and clinical features of these tumors in order to better understand their features. This is a retrospective study of 196 secondary lesions involving the gynecologic tract. The parameters studied were the primary site, its histologic type and grade, the presence of mucous production, the type of secondary involvement, defined as distant metastasis, direct extension or locoregional recurrence, and the time to metastasis. Organs involved were the ovary (50%), the vagina (22%), the myometrium (10.7%), the cervix (10.2%), the endometrium (3.6%), the vulva (2%), and the Fallopian tube (1.5%). Most often, primary tumors were colorectal (39.8%), endometrial (15.3%), breast (12.7%), ovarian (10.7%), and gastric (5.6%). Secondary tumors were metachronous in 43.9% of the cases with a mean time to recurrence of 55.5 mo. Distant metastases were the most common type of secondary involvement (64.8%), followed by direct extension (19.9%) and local ...Continue Reading

References

May 1, 1984·Cancer·M T MazurD J Gersell
May 27, 2003·The American Journal of Surgical Pathology·Antonio G NetoAnais Malpica
Sep 2, 2011·The American Journal of Surgical Pathology·Peiguo G ChuSean K Lau
Apr 19, 2012·The American Journal of Surgical Pathology·Maria Carolina ReyesSamson W Fine
Feb 8, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N HugenI D Nagtegaal
Jan 4, 2015·Gynecologic Oncology·Matthew M HarkenriderWilliam Small
Feb 3, 2016·Journal of the National Cancer Institute·Michael S AnglesioDavid G Huntsman
Mar 5, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Veysel SalMacit Arvas
Feb 28, 2017·Pathology·Georgia KarpathiouMichel Peoc'h
Mar 23, 2017·Annals of Diagnostic Pathology·Georgia KarpathiouMichel Peoc'h
Jul 22, 2017·Clinical & Experimental Metastasis·Ondřej KubečekStanislav Filip
Aug 11, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Georgia KarpathiouMichel Peoc'h
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N HugenI D Nagtegaal

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Citations

Sep 11, 2020·The American Journal of Surgical Pathology·Gulisa TurashviliLars-Christian Horn
Nov 21, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Anne-Sophie BouvierCamille Mimoun
Mar 9, 2021·Frontiers in Oncology·Biyuan XingYingchao Zhao

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