Secondhand Smoking Is Associated With Vascular Inflammation

Chest
Tessa AdamsSanja Jelic

Abstract

The relative risk for cardiovascular diseases in passive smokers is similar to that of active smokers despite almost a 100-fold lower dose of inhaled cigarette smoke. However, the mechanisms underlying the surprising susceptibility of the vascular tissue to the toxins in secondhand smoke (SHS) have not been directly investigated. The aim of this study was to investigate directly vascular endothelial cell function in passive smokers. Using a minimally invasive method of endothelial biopsy, we investigated directly the vascular endothelium in 23 healthy passive smokers, 25 healthy active smokers, and 23 healthy control subjects who had never smoked and had no regular exposure to SHS. Endothelial nitric oxide synthase (eNOS) function (expression of basal eNOS and activated eNOS [phosphorylated eNOS at serine1177 (P-eNOS)]) and expression of markers of inflammation (nuclear factor-κB [NF-κB]) and oxidative stress (nitrotyrosine) were assessed in freshly harvested venous endothelial cells by quantitative immunofluorescence. Expression of eNOS and P-eNOS was similarly reduced and expression of NF-κB was similarly increased in passive and active smokers compared with control subjects. Expression of nitrotyrosine was greater in active ...Continue Reading

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Citations

Jul 8, 2015·Chest·Laura E Crotty Alexander, Atul Malhotra
Nov 16, 2016·International Journal of Environmental Research and Public Health·S Christy SadreameliJohn J Strouse
May 15, 2018·International Journal of Environmental Research and Public Health·Jingya HuangXiaohua Ye
Aug 9, 2017·Journal of Cellular Biochemistry·Junfeng DuMin Li
Sep 14, 2018·Current Vascular Pharmacology·Saeid GolbidiIsmail Laher
Jun 26, 2020·International Dental Journal·Sachi UmemoriKatsunori Kondo
Jan 4, 2019·International Journal of Environmental Research and Public Health·Sydne I DiGiacomoJohn A Ambrose
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Apr 11, 2019·International Journal of Environmental Research and Public Health·Xiaohua YeYanjun Xu
Mar 19, 2016·Epidemiology and Health·Na Hyun KimHyeon Chang Kim
Feb 1, 2020·Journal of Ethnopharmacology·Daniel Silveira SerraAntônia Torres Ávila Pimenta
Oct 13, 2017·Atherosclerosis·Natalie Ly Ngu, Mark McEvoy

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