Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma

International Journal of Molecular Sciences
Vanessa Martínez-RiveraBlanca Ortiz-Quintero

Abstract

Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates in the pleura, is diagnosed in advanced stages and has a poor prognosis. Accurate diagnosis of MPM is often difficult and complex, and the gold standard diagnosis test is based on qualitative analysis of markers in pleural tissue by immunohistochemical staining. Therefore, it is necessary to develop quantitative and non-subjective alternative diagnostic tools. MicroRNAs are non-coding RNAs that regulate essential cellular mechanisms at the post-transcriptional level. Recent evidence indicates that miRNA expression in tissue and body fluids is aberrant in various tumors, revealing miRNAs as promising diagnostic biomarkers. This review summarizes evidence regarding secreted and tissue miRNAs as biomarkers of MPM and the biological characteristics associated with their potential diagnostic value. In addition to studies regarding miRNAs with potential diagnostic value for MPM, studies that aimed to identify the miRNAs involved in molecular mechanisms associated with MPM development are described with an emphasis on relevant aspects of the experimental designs that may influence the accuracy, consistency and real diagnostic value of currently reporte...Continue Reading

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Citations

Aug 15, 2018·International Journal of Environmental Research and Public Health·Małgorzata Krówczyńska, Ewa Wilk
Nov 15, 2018·International Journal of Molecular Sciences·Emanuela Felley-Bosco
Mar 3, 2020·Journal of Toxicology and Environmental Health. Part a·Kihun KimYun Hak Kim
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Jan 20, 2021·Cancer Cytopathology·Albino EccherLiron Pantanowitz
Jun 15, 2021·Frontiers in Molecular Biosciences·Jieqing YuJing Ye

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Methods Mentioned

BETA
X-ray
PCR
biopsy
acetylation
PCRArray

Software Mentioned

PCRArray
OpenArray

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