Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Neuron
Christian Haass, Michael Willem

Abstract

The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.

Citations

Nov 30, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Dimitri HefterMartin Korte
Jul 1, 2020·Journal of Alzheimer's Disease : JAD·Maria ChatzistavrakiSpiros Efthimiopoulos
Jun 27, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard J CaselliGuojun Bu
May 15, 2021·Nature Reviews. Disease Primers·David S KnopmanDavid T Jones

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