Secreted factors as synaptic organizers.

The European Journal of Neuroscience
Erin M Johnson-Venkatesh, Hisashi Umemori

Abstract

A critical step in synaptic development is the differentiation of presynaptic and postsynaptic compartments. This complex process is regulated by a variety of secreted factors that serve as synaptic organizers. Specifically, fibroblast growth factors, Wnts, neurotrophic factors and various other intercellular signaling molecules are proposed to regulate presynaptic and/or postsynaptic differentiation. Many of these factors appear to function at both the neuromuscular junction and in the central nervous system, although the specific function of the molecules differs between the two. Here we review secreted molecules that organize the synaptic compartments and discuss how these molecules shape synaptic development, focusing on mammalian in vivo systems. Their critical role in shaping a functional neural circuit is underscored by their possible link to a wide range of neurological and psychiatric disorders both in animal models and by mutations identified in human patients.

References

Oct 1, 1992·Current Opinion in Cell Biology·U J McMahanG Escher
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·U J McMahan
Aug 1, 1996·Cytokine & Growth Factor Reviews·A R GoodmanJ Vilcek
Feb 14, 1998·Nature Medicine·M ZhouT Doetschman
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D G WellsJ R Fallon
Apr 15, 1999·Annual Review of Neuroscience·J R Sanes, J W Lichtman
Feb 7, 2001·Science·E M UllianB A Barres
Mar 29, 2001·Genome Biology·D M Ornitz, N Itoh
Apr 12, 2001·The European Journal of Neuroscience·C CollinM Segal
Jul 20, 2001·Molecular and Cellular Neurosciences·N BelluardoC F Ibáñez
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Nov 21, 2001·Nature Reviews. Neuroscience·J R Sanes, J W Lichtman
Dec 6, 2001·Nature Reviews. Neuroscience·D L BensonG W Huntley
Feb 12, 2002·Nature Neuroscience·Beatriz RicoLouis F Reichardt
Jul 3, 2002·Molecular and Cellular Neurosciences·Anita C HallPatricia C Salinas
Oct 31, 2002·The European Journal of Neuroscience·Ai-Jun LiToru Imamura
Dec 4, 2002·Neurobiology of Disease·Maija CastrénEero Castrén
Feb 4, 2003·The Journal of Physiology·David KnightPeter G Noakes
Mar 11, 2003·Annual Review of Neuroscience·Peter Scheiffele
Oct 15, 2003·Neuron·Yukiko Goda, Graeme W Davis
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarina B ElmariahRita J Balice-Gordon
Feb 15, 2005·Cell·Karen S ChristophersonBen A Barres
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan W LuikartLuis F Parada
Jul 19, 2005·Annual Review of Neuroscience·Clarissa L WaitesCraig C Garner

❮ Previous
Next ❯

Citations

Nov 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lorena Varela-NallarNibaldo C Inestrosa
Jun 1, 2012·Molecular Biology of the Cell·Cheng ChenH Benjamin Peng
Apr 22, 2011·Journal of Biochemistry·Ania Dabrowski, Hisashi Umemori
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hyejin LeeEunjoon Kim
Nov 29, 2014·Molecular Neurobiology·Waldo CerpaNibaldo C Inestrosa
May 25, 2015·Molecular and Cellular Neurosciences·Iván E AlfaroNibaldo C Inestrosa
Mar 18, 2011·The European Journal of Neuroscience·Keiko Matsuda, Michisuke Yuzaki
Jul 22, 2010·The European Journal of Neuroscience·Michisuke Yuzaki
Jun 16, 2015·Frontiers in Cellular Neuroscience·Timothy J Mosca
Feb 24, 2011·Current Opinion in Neurobiology·Michisuke Yuzaki
Mar 29, 2014·Frontiers in Synaptic Neuroscience·Aislinn J Williams, Hisashi Umemori
Jun 18, 2016·Journal of Neurochemistry·Maria J Pinto, Ramiro D Almeida
Mar 23, 2017·Journal of Neurochemistry·Michela Rigoni, Cesare Montecucco
Aug 17, 2012·Nature Reviews. Neuroscience·R Jeroen Pasterkamp
Aug 29, 2020·Science·Kunimichi SuzukiMichisuke Yuzaki
Jun 10, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Akiko Terauchi, Hisashi Umemori
Oct 12, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yosuke Kitahara, Akinori Nishi
Sep 29, 2020·Frontiers in Molecular Neuroscience·Federica BriatoreAnnarita Patrizi
Apr 4, 2021·Journal of Developmental Biology·Alison T DePew, Timothy J Mosca
Nov 29, 2014·Journal of Cell Science·Akiko TerauchiHisashi Umemori
May 1, 2015·Development·Ania DabrowskiHisashi Umemori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.