Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders

The Journal of Investigative Dermatology
Misun KimHee Young Kang

Abstract

In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via β-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.

Citations

Jun 9, 2016·Annals of Dermatology·Emanuela BastoniniMauro Picardo
Nov 14, 2018·Experimental Dermatology·Soon-Hyo KwonKyoung-Chan Park
Dec 24, 2018·Experimental Dermatology·Misun KimHee Young Kang
May 31, 2016·International Journal of Molecular Sciences·Soon-Hyo KwonKyoung-Chan Park
Jan 8, 2016·Experimental Dermatology·Ranesha GoorochurnPhilippe Humbert
Dec 30, 2017·Pigment Cell & Melanoma Research·Thierry Passeron, Mauro Picardo
May 12, 2017·The British Journal of Dermatology·X H Yuan, Z H Jin
Oct 20, 2020·Pharmacology & Therapeutics·Xiaoyu TianRutao Cui
Mar 16, 2021·The Journal of Clinical Investigation·Asurayya WorredeAshani T Weeraratna
May 26, 2021·Journal of Dermatological Science·Chi-Hyun ParkJin Ho Chung
May 29, 2021·Pigment Cell & Melanoma Research·Hee Young KangMauro Picardo
Aug 20, 2021·Journal of Cosmetic Dermatology·Ofir ArtziJacob Mashiah
Sep 3, 2021·Developmental Cell·Meng-Yen LiElena Ezhkova
May 18, 2020·The Journal of Investigative Dermatology·Yeongeun KimHee Young Kang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.