Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

Biochemical and Biophysical Research Communications
Peng YangZhuoyu Li

Abstract

Pyruvate Kinase M2 (PKM2) is a key glycolytic enzyme, which highly expressed in tumor cells, and plays a pivotal role in the growth, survival and metabolism reprogramming of cancer cells. Besides the location of cytoplasm as a glycolytic enzyme and the location of nucleus as a protein kinase, extracellular PKM2 is present in serum and feces of tumor patients. However, little is known about the secretion of PKM2 and its significance in the progression of colon cancer. Here we demonstrated that PKM2 could be secreted from colon cancer cells, and purified PKM2 protein mimicing the secreted PKM2 was able to promote colon cancer cell migration. Moreover, PI3K/Akt and Wnt/β-catenin signaling were involved in secreted PKM2 induced colon cancer cell migration. The results reveal critical roles of secreted PKM2 in the progression of colon cancer, and indicate that PKM2 may be a therapeutic target for colon cancer.

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Citations

Oct 27, 2015·Cellular and Molecular Life Sciences : CMLS·Zhaoyong Li, Huafeng Zhang
Nov 25, 2016·Scientific Reports·Raju V S RajalaRobert E Anderson
Dec 13, 2018·American Journal of Physiology. Renal Physiology·Wei ZhangQingjuan Liu
Jan 5, 2017·Molecular Pharmacology·Yannick Audet-DelageChantal Guillemette
Jan 7, 2020·Journal of Cellular Physiology·Cecilia EvangelistiCamilla Evangelisti
Sep 24, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hyunju KimSo Yeon Kim
Aug 9, 2019·Cell & Bioscience·Ze ZhangFangfang Chen
Feb 13, 2020·International Journal of Molecular Sciences·Francesca ChiariniCamilla Evangelisti
Oct 23, 2019·Scientific Reports·Jesús Gómez-EscuderoAlicia G Arroyo
Dec 15, 2020·American Journal of Physiology. Endocrinology and Metabolism·Vinodkumar B Pillai, Mahesh P Gupta
Jul 27, 2021·Journal of Cellular Physiology·Yoon-Beom LeeJae-Bong Park
Aug 23, 2017·Journal of Agricultural and Food Chemistry·Shuhua ShanZhuoyu Li

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