Secreted subtilisins of Microsporum canis are involved in adherence of arthroconidia to feline corneocytes

Journal of Medical Microbiology
Aline BaldoB R Mignon

Abstract

Microsporum canis is a pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis, mainly in cats and humans. The mechanisms involved in adherence of M. canis to epidermis have never been investigated. Here, a model was developed to study the adherence of M. canis to feline corneocytes through the use of a reconstructed interfollicular feline epidermis (RFE). In this model, adherence of arthroconidia to RFE was found to be time-dependent, starting at 2 h post-inoculation and still increasing at 6 h. Chymostatin, a serine protease inhibitor, inhibited M. canis adherence to RFE by 53%. Moreover, two mAbs against the keratinolytic protease subtilisin 3 (Sub3) inhibited M. canis adherence to RFE by 23%, suggesting that subtilisins, and Sub3 in particular, are involved in the adherence process.

References

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Citations

Jul 10, 2012·Veterinary Microbiology·Elena Tatiana BăguţBernard Mignon
Jun 30, 2018·Experimental Dermatology·Émilie FawayYves Poumay
Jan 24, 2018·Medical Mycology·Derry K Mercer, Colin S Stewart
Jul 5, 2019·Mycoses·Priscilla Maciel QuatrinAlexandre Meneghello Fuentefria
Dec 15, 2010·Anais Brasileiros De Dermatologia·Nalu Teixera de Aguiar PeresNilce Maria Martinez-Rossi
Oct 13, 2016·Mycopathologia·Ludivine CambierBernard Mignon
Jun 4, 2019·Biofouling·Raimunda Sâmia Nogueira BrilhanteDébora de Souza Collares Maia Castelo-Branco

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