PMID: 6408298Mar 15, 1983Paper

Secretin versus somatostatin in acute hemorrhage of gastroduodenal ulcers and erosions: a randomized trial

Klinische Wochenschrift
P K WagnerJ Grönniger

Abstract

In a randomized trial the efficiency of synthetic secretin (0,25 clinical units/kg bw/h; 15 patients) was compared with that of synthetic somatostatin (250 micrograms/h, 15 patients) in treatment of severe acute non arterial bleeding from peptic ulcers or stress lesions in the upper digestive tract. In all patients the presence of hemorrhage at beginning of the therapy was established by endoscopic examination. Both test preparations were given as continuous infusions over 48 h and had identical effects on the hemorrhage: in 12 patients (80%) out of each group bleeding stopped during the infusion of secretin or somatostatin, 6 patients (20%) had to be operated on for persistant bleeding or severe recurrence.

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Citations

Jan 1, 1988·Langenbecks Archiv für Chirurgie·P K Wagner
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·I Magnusson
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J Christiansen, A Yotis
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·R StaveM Osnes
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·M Tryba, B May
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·W LondongA König

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