Secretion and metabolism of cortisol and aldosterone during controlled hyperthermia

The Journal of Physiology
K J Collins, J D Few

Abstract

1. The rates of secretion and metabolic clearance of cortisol and aldosterone in response to passive heating have been investigated in fifteen young men by the controlled hyperthermia technique combined with continuous I.V. infusion of [14C]cortisol and [3H]aldosterone. 2. During a 1 hr period of elevation of deep body temperature to 38.0 degrees C mean hepatic blood flow measured by indocyanine green clearance decreased by more than 25% compared with normothermic condition. 3. The pattern of response in hyperthermia involved decreasing plasma specific activities indicating increased adrenal secretion of both cortisol and aldosterone. 4. Aldosterone metabolic clearance rate usually decreased in hyperthermia when there was little change in the clearance rate of cortisol, but an increased aldosterone clearance rate was observed when there were significant increases in the clearance rate of cortisol. A contributing factor to elevation of plasma aldosterone concentration in the heat is the reduction in hepatic blood flow which reduces aldosterone metabolic clearance rate. 5. Suppression of the thermally induced rise in plasma cortisol concentration by dexamethasone was associated with a decrease in aldosterone clearance rate which ...Continue Reading

Citations

Nov 19, 2004·International Journal of Biometeorology·Shigeki NomotoWalter Riedel
Jun 1, 1989·International Journal of Biometeorology·E AssiaE Sohar
Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·J D FewG Turton
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·V CandasJ P Libert
Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·G BrandenbergerJ M Kahn
May 15, 2007·American Journal of Nephrology·Seham MustafaMerci Mathew
Jan 31, 2020·The Journal of Clinical Endocrinology and Metabolism·Baha M Arafah
Sep 1, 1980·Annals of Clinical Biochemistry·J D Few, G C Cashmore

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