PMID: 3214432Nov 1, 1988Paper

Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes

The Biochemical Journal
J M Duerden, G F Gibbons

Abstract

Hepatic lipid synthesis was measured in rats in vivo with 3H2O, and the appearance of label in triacylglycerol and its constituent fatty acid and glycerol moieties was determined. In rats treated with Triton WR1339, the amount of newly synthesized fatty acid secreted as very-low-density lipoprotein (VLDL) triacylglycerol was greater during the dark phase of the diurnal cycle than during the light phase (11.3 versus 4.8 mumol of 3H2O/3 h per g of liver respectively). However, the total mass of VLDL triacylglycerol secreted remained constant, as did the amount of label in the secreted triacylglycerol glycerol. Newly synthesized fatty acids comprised only a small proportion of the total VLDL triacylglycerol fatty acids (TGFA) at both times (dark phase, 7.7%; light phase, 2.4%). Starvation for 24 h resulted in a small increase in the secretion of VLDL triacylglycerol. However, the contribution from newly synthesized fatty acids was decreased. Similar effects were observed in streptozotocin-diabetic animals. During the light and dark phases of the cycle, similar quantities of newly synthesized TGFA entered the hepatic cytosol, and these amounts were much smaller than those secreted as VLDL triacylglycerol. The mass of cytosolic tria...Continue Reading

Citations

Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ethel V LarregleMaría S Giménez
Dec 1, 2006·Nature·Eugenio GutierrezAlex P Gould
Sep 19, 2007·Journal of Nutritional Science and Vitaminology·Junichi MatsumotoKiyoshi Ebihara
Jul 2, 2015·American Journal of Physiology. Endocrinology and Metabolism·Charlotte J GreenLeanne Hodson
Dec 1, 1992·The American Journal of Physiology·P J CampbellN Nurjhan
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·W WangM K Hellerstein
May 19, 2005·The Journal of Biological Chemistry·Daniel Duran-SandovalBart Staels
Oct 30, 2014·American Journal of Physiology. Endocrinology and Metabolism·Charlotte J GreenLeanne Hodson
Oct 1, 1992·The American Journal of Physiology·O L FranconeA D Kalopissis
Aug 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N M DelzenneH S Taper
Mar 5, 1999·Biochimica Et Biophysica Acta·M C SugdenM J Holness

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