Secretion of autoimmune antibodies in the human subcutaneous adipose tissue

PloS One
Daniela FrascaBonnie B Blomberg

Abstract

The adipose tissue (AT) contributes to systemic and B cell intrinsic inflammation, reduced B cell responses and secretion of autoimmune antibodies. In this study we show that adipocytes in the human obese subcutaneous AT (SAT) secrete several pro-inflammatory cytokines and chemokines, which contribute to the establishment and maintenance of local and systemic inflammation, and consequent suboptimal immune responses in obese individuals, as we have previously shown. We also show that pro-inflammatory chemokines recruit immune cells expressing the corresponding receptors to the SAT, where they also contribute to local and systemic inflammation, secreting additional pro-inflammatory mediators. Moreover, we show that the SAT generates autoimmune antibodies. During the development of obesity, reduced oxygen and consequent hypoxia and cell death lead to further release of pro-inflammatory cytokines, "self" protein antigens, cell-free DNA and lipids. All these stimulate class switch and the production of autoimmune IgG antibodies which have been described to be pathogenic. In addition to hypoxia, we have measured cell cytotoxicity and DNA damage mechanisms, which may also contribute to the release of "self" antigens in the SAT. All th...Continue Reading

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Citations

Mar 29, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Calvin C ChanSenad Divanovic
May 12, 2019·Acta Physiologica·Ioannis G LempesisGijs H Goossens
Mar 7, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Prasad Srikakulapu, Coleen A McNamara
Jan 28, 2020·Annual Review of Immunology·Michael P Cancro
Jul 10, 2019·PloS One·Daniela FrascaBonnie B Blomberg
Jan 11, 2020·Frontiers in Immunology·Jarren R OatesSenad Divanovic
Mar 18, 2020·Frontiers in Immunology·Daniela FrascaBonnie B Blomberg
Jul 8, 2020·Current Obesity Reports·Christina TsigalouMaria Dalamaga
Sep 29, 2020·Frontiers in Immunology·Daniela Frasca, Bonnie B Blomberg
Sep 11, 2020·Current Cardiology Reports·Elena C CastilloGuillermo Torre-Amione
Aug 14, 2020·Seminars in Immunopathology·Daniela Frasca, Bonnie B Blomberg
Oct 7, 2020·Annual Review of Cell and Developmental Biology·Daniela FrascaBonnie B Blomberg
Mar 1, 2021·Immunity & Ageing : I & a·Daniela FrascaBonnie B Blomberg
Mar 7, 2021·International Journal of Molecular Sciences·Daniela FrascaBonnie B Blomberg
May 1, 2021·Pharmaceuticals·Moon Kyung ChoeHyo Joon Kim
Aug 15, 2019·Gerontology·Daniela Frasca, Bonnie B Blomberg

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Methods Mentioned

BETA
PMA
Fluorescence
flow cytometry
ELISA
protein array
RNA assay

Software Mentioned

FlowJo
AlphaEaseFC
GraphPad Prism

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