Secretion of cytokines by natural killer cells primed with interleukin-2 and stimulated with different lipoproteins

Immunology
J B De SanctisN E Bianco

Abstract

Natural killer (NK) cells were shown to secrete differentially interleukins (IL), IL-1 alpha, IL-1 beta, IL-2, IL-8, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), and leukaemia inhibitory factor (LIF) upon stimulation with optimal concentrations of chylomicrons (CM), very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein (HDL) or acetyl-modified low-density lipoprotein (AcLDL). CM, VLDL, LDL and AcLDL induced LIF secretion which was absent in nonstimulated cells. CM, VLDL, and LDL did not affect IL-1 alpha secretion. CM stimulated IL-8 > TNF-alpha > IL-1 alpha > IL-2 = IFN-gamma, and decreased seventeen-fold GM-CSF secretion. VLDL stimulated IL-8 secretion > IL-1 alpha = IL-2 > IFN-gamma > TNF-alpha and decreased fivefold GM-CSF secretion. LDL stimulated IL-8 secretion > IL-1 alpha > IL-2 = IFN-gamma, it did not modify TNF-alpha and inhibited five hundred-fold GM-CSF secretion. HDL stimulated IL-2 secretion = IFN-gamma > IL-8, it decreased GM-CSF secretion > IL-1 alpha > IL-1 beta > TNF-alpha without affecting LIF. AcLDL stimulated IL-8 secretion > TNF-alpha > IL-1 alpha > IL-2 = IFN-gamma = IL-1 beta, and ...Continue Reading

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Citations

Jul 20, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Lev E PaninIrina M Korostyshevskaya
Jun 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tomiya YasumasuYasuhide Nakashima
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May 5, 2017·British Journal of Pharmacology·Tin KyawAlex Bobik
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Sep 12, 2020·Current Drug Targets·Adekunle Babajide RowaiyeCharles Okechukwu Esimone

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