PMID: 9642203Jun 27, 1998Paper

Secretion of elastinolytic enzymes and their propeptides by Pseudomonas aeruginosa

Journal of Bacteriology
P BraunJ Tommassen

Abstract

Elastase of Pseudomonas aeruginosa is synthesized as a preproenzyme. The signal sequence is cleaved off during transport across the inner membrane and, in the periplasm, proelastase is further processed. We demonstrate that the propeptide and the mature elastase are both secreted but that the propeptide is degraded extracellularly. In addition, reduction of the extracellular proteolytic activity led to the accumulation of unprocessed forms of LasA and LasD in the extracellular medium, which shows that these enzymes are secreted in association with their propeptides. Furthermore, a hitherto undefined protein with homology to a Streptomyces griseus aminopeptidase accumulated under these conditions.

References

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Citations

Apr 20, 2001·Molecular Microbiology·M Sandkvist
May 15, 2001·The Journal of Biological Chemistry·P BraunJ Tommassen
Mar 29, 2003·Archives of Microbiology·Wilbert Bitter
Jan 2, 2004·Microbiology·Lindsey ShawSimon J Foster
Mar 3, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Sara M McCartySteven L Percival
Dec 10, 2014·Journal of Bacteriology·Ian J PassmoreMartin Welch
Aug 24, 2010·Biotechnology and Applied Biochemistry·Chee Fah WongRaja Noor Zaliha Raja Abd Rahman
Jan 3, 2001·Journal of Bacteriology·A UrbanK E Jaeger
Feb 15, 2000·Journal of Bacteriology·J FoldersW Bitter
Jul 20, 2001·Current Eye Research·L G AlionteJ A Hobden
Aug 9, 2003·Microbiology·C R CorbettP A Sokol
Aug 17, 2011·Applied Microbiology and Biotechnology·Ji-Wei Wu, Xiu-Lan Chen
Oct 1, 2010·Biomolecular Concepts·Ilya V DemidyukSergey V Kostrov
Nov 14, 2014·Chemical Biology & Drug Design·Erin E GillRobert E W Hancock
Dec 31, 2016·The Journal of Microbiology·Mohammed Abd Alrahman, Sang Sun Yoon
Nov 22, 2001·Journal of Bacteriology·J FoldersW Bitter
Dec 17, 2015·Nature Reviews. Urology·Massimo AlfanoAndrea Salonia
Nov 6, 2020·Science Progress·Suzanne Forrest, Martin Welch
Mar 7, 2021·Drug Discovery Today·Martin J Everett, David T Davies
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Walid A LotfyEhab R El-Helow
Mar 16, 2000·Microbes and Infection·S Miyoshi, S Shinoda
May 18, 2018·Journal of Proteome Research·Charlotte GaviardJulie Hardouin
Oct 25, 2008·International Journal of Medical Microbiology : IJMM·Philipp Wolf, Ursula Elsässer-Beile
Jun 2, 2009·Journal of Biotechnology·Joanna KrzeslakWim J Quax

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