PMID: 1206529Nov 1, 1975Paper

Secretion of electrolytes by the pancreas of the anaestetized rat

The Journal of Physiology
W A Sewell, J A Young

Abstract

1. HCO-3, Na+ and K+ concentrations were measured in bile-free pancreatic juice collected from fasted and fed anaesthetized rats. 2. Resting flow rates averaged 0.62 mul. g-1 .min-1 (fasted) and 2.8 mul. g-1. min-1 (fed) and the mean HCO-3 concentrations, respectively, were 25.8 and 33.3 mM. 3. In fasted rats, instillation of HCl into the duodenum caused flow rate to increase threefold and HCO-3 concentrations to double (66 mM). Intravenous infusion of pure natural (GIH) secretin caused a fivefold increase in flow rate; HCO-3 concentrations, again, doubled (67.5 mM). Infusion of synthetic secretin produced effects essentially the same as those produced by GIH secretin. 4. Infusion of Boots secretin caused a thirteenfold increase in flow rate (8.32 mul.g-1. min-1) but HCO-3 concentrations rose only slightly (43.3 mM). However, following cessation of infusion, when flow rate approximated the maximum obtained with pure secretin, the HCO-3 concentration was much higher (57.2 mM at 3.19 uml.g-1.min-1). In fed animals the responses were similar but maximum flow rates were greater (12 mul. g-1. min-1). 5. Infusion of caerulein produced a secretory rate slightly less than with Boots secretin (5.06 mul. g-1.min-1) and HCO-3 concentratio...Continue Reading

Citations

Dec 1, 1979·Pflügers Archiv : European journal of physiology·A PapH Sarles
May 1, 1990·The Journal of Membrane Biology·M A GrayB E Argent
Aug 1, 1991·Pflügers Archiv : European journal of physiology·I Novak, R Greger
Feb 19, 2002·The Journal of Physiology·H IshiguroM C Steward
Jan 1, 1980·Annals of the New York Academy of Sciences·I Schulz
Jan 1, 1985·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Jul 31, 2014·Pflügers Archiv : European journal of physiology·Viktória VengloveczPéter Hegyi
Feb 16, 2005·Annual Review of Physiology·Martin C StewardR Maynard Case
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M K ParkO H Petersen
Dec 21, 2016·The Journal of Physiology·Makoto YamaguchiHiroshi Ishiguro
Jun 1, 1997·Microscopy Research and Technique·C Weaver
Feb 24, 2004·The Journal of Physiology·M Paz Fernández-SalazarJosé I San Román
Aug 1, 1993·Pflügers Archiv : European journal of physiology·C Pahl, I Novak
Jan 1, 1988·Pflügers Archiv : European journal of physiology·C RandriamampitaA Trautmann
Mar 1, 1980·Pflügers Archiv : European journal of physiology·R LaugierH Sarles
Jan 1, 1986·Pflügers Archiv : European journal of physiology·L A EvansJ A Young
Jan 18, 2011·Journal of Bacteriology·Carsten KrögerThilo M Fuchs
Apr 28, 1978·Annals of the New York Academy of Sciences·O H Peterson, N Iwatsuki
Dec 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mitsuyoshi YamamotoGary M Green
Feb 28, 2009·Journal of Physiology and Biochemistry·M GarcíaJ J Calvo
Oct 28, 2010·The Journal of Biological Chemistry·Ivana NovakSusanne E Hede
Feb 3, 2012·Physiological Reviews·Min Goo LeeShmuel Muallem
Apr 25, 2003·American Journal of Physiology. Cell Physiology·Peying FongMichael A Gray
Aug 22, 2013·Channels·Mikio Hayashi, Ivana Novak
Nov 14, 2019·International Journal of Molecular Sciences·Mikio Hayashi
Oct 31, 2002·The Journal of General Physiology·H IshiguroS Naruse
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Eitan Gross, Ira Kurtz
Dec 12, 2018·Scientific Reports·Carsten KrögerThilo M Fuchs
May 5, 2012·American Journal of Physiology. Cell Physiology·Mikio HayashiIvana Novak
Feb 1, 2013·American Journal of Physiology. Cell Physiology·Jing WangIvana Novak
Sep 13, 2014·Molecular Microbiology·Johannes E RothhardtThilo M Fuchs
Dec 1, 1988·The American Journal of Physiology·K W GasserU Hopfer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.