Secretion of IgA by rat parotid and submandibular cells in response to autonomimetic stimulation in vitro

International Immunopharmacology
G H CarpenterJ R Garrett

Abstract

The major antibody in saliva is IgA, which is actively transported by pIgR expressed by parenchymal cells within the salivary glands. The rate of IgA secretion into saliva is regulated by the autonomic nerves supplying the glands in vivo. This study examined the mechanism of increased IgA secretion into saliva with autonomimetic stimulation. In vitro stimulation of IgA secretion from cells prepared by digestion of rat salivary glands found submandibular cell preparations responded to alpha- and beta-adrenergic stimuli whereas the parotid cells responded only to beta-adrenergic stimulation, although cells from both glands responded similarly to cholinergic stimulation. The additional responsiveness of submandibular cells to alpha-adrenergic stimulation probably reflects the presence of granular duct cells (absent in parotid glands) which are known to secrete protein in response to high frequency sympathetic stimulation. The increased secretion of IgA was not dependant upon increased plasma cell activation since isolated salivary gland plasma cells did not respond to agonists. Further evidence for the regulating role of parenchymal cells in IgA secretion into saliva was revealed by analysis of polymeric immunoglobulin receptor (p...Continue Reading

References

Nov 1, 1978·The American Journal of Physiology·B I Bogart, J Picarelli
Jan 1, 1986·Archives of Oral Biology·L C Anderson
Jan 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R SolariJ P Kraehenbuhl
Jan 1, 1982·Immunological Communications·I Lemaître-CoelhoJ P Vaerman
May 1, 1995·Immunological Investigations·J P VaermanC Vander Maelen
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·W SongK Mostov
Oct 9, 1998·The Journal of Physiology·G H CarpenterG B Proctor
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J KasprowiczV M Sanders
May 31, 2001·Journal of Dental Research·G B Proctor, G H Carpenter

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Citations

Mar 15, 2005·European Journal of Applied Physiology·E TiollierJ-P Richalet
Mar 18, 2008·Journal of Sports Sciences·Judith E AllgroveMichael Gleeson
May 15, 2010·The Journal of Veterinary Medical Science·Yoshihiro MunetaYoshitaka Omata
Jan 18, 2005·Biological Chemistry·Wijnand TeeuwArie V Nieuw Amerongen
Mar 29, 2014·Cell Death & Disease·S S BozorgiG H Carpenter
Feb 20, 2007·Acta Physiologica·G H CarpenterG B Proctor
Aug 9, 2016·Bioscience, Biotechnology, and Biochemistry·Yuki KurimotoKeiichi Tsukinoki
Aug 19, 2007·Molecular Immunology·Maaike StoelNicolaas A Bos
Jan 16, 2007·International Journal of Experimental Pathology·Samira M OsailanMark McGurk
Mar 17, 2006·Medicine and Science in Sports and Exercise·Nicolette C BishopEleanor Rogers
Feb 13, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mariana F LeiteMaria Teresa B Santos
Dec 12, 2018·Journal of Prosthodontic Research·Akihiro IshidaKaoru Sakurai
Aug 16, 2017·Journal of the International Society of Sports Nutrition·Kay Rutherfurd-MarkwickAjmol Ali
Jul 19, 2021·Archives of Oral Biology·Ken OkabayashiTakanori Narita
Jun 26, 2007·Psychoneuroendocrinology·Adriana Jarillo-LunaRafael Campos-Rodríguez
Sep 15, 2009·Brain, Behavior, and Immunity·Humberto Reyna-GarfiasRafael Campos-Rodríguez
Oct 19, 2021·Frontiers in Immunology·Desiree AntequeraEva Carro

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