Secretion of interferon gamma from human immune cells is altered by exposure to tributyltin and dibutyltin.

Environmental Toxicology
Shanieek LawrenceMargaret Whalen

Abstract

Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα) from human immune cells in vitro. The capacity of BTs to interfere with secretion of other pro-inflammatory cytokines has not been examined. Interferon gamma (IFNγ) is a modulator of adaptive and innate immune responses, playing an important role in overall immune competence. This study shows that both TBT and DBT alter secretion of IFNγ from human immune cells. Peripheral blood cell preparations that were increasingly reconstituted were used to determine if exposures to either TBT or DBT affected IFNγ secretion and how the makeup of the cell preparation influenced that effect. IFNγ secretion was examined after 24 h, 48 h, and 6 day exposures to TBT (200 - 2.5 nM) and DBT (5 - 0.05 µM) in highly enriched human NK cells, a monocyte-depleted preparation of PBMCs, and monocyte-containing PBMCs. Both BTs altered IFNγ secretion from immune cells at most of the conditions tested (either increasing or decrea...Continue Reading

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Citations

Mar 14, 2018·Journal of Applied Toxicology : JAT·Shanieek LawrenceMargaret M Whalen
Aug 26, 2017·Journal of Applied Toxicology : JAT·Shyretha BrownMargaret Whalen
Jun 29, 2018·Archives of Toxicology·Shyretha BrownMargaret Whalen
Sep 8, 2016·Journal of Immunotoxicology·Shanieek LawrenceMargaret M Whalen
May 18, 2016·Journal of Applied Toxicology : JAT·Shyretha BrownMargaret M Whalen
Oct 4, 2017·PeerJ·Chean Yeah YongWen Siang Tan

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