PMID: 10011Oct 21, 1976

Secretion of lecithin: cholesterol acyltransferase from isolated rat hepatocytes

Biochimica Et Biophysica Acta
G NordbyK R Norum

Abstract

1. Lecithin:cholesterol acyltransferase is secreted from isolated rat heptocytes. 2. The secretion is stimulated when serum is added to the incubation medium. 3. Optimal conditions for secretion are: 5-10(6) hepatocytes per ml, 5 h incubation, pH 7.3-7.4 and 25% serum in the incubation medium. 4. Concomitantly with the secretion of lecithin:cholesterol acyltransferase there is a secretion of unesterified cholesterol and triacylglycerol. 5. Colchicine or cycloheximide in the incubation medium inhibits secretion of lecithin:cholesterol acyltransferase.

References

Jun 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·J H HANKS, R E WALLACE

Citations

Apr 29, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·M NanjeeN E Miller
Jan 1, 1986·Mechanisms of Ageing and Development·S I CarlileA G Lacko
Jan 1, 1979·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B H Dannevig, K R Norum
Apr 15, 1978·FEBS Letters·J Norseth, B O Christophersen
Dec 1, 1982·Clinical Biochemistry·J FrohlichK Hon
Dec 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·T A Hagve, B O Christophersen
Dec 1, 1979·Gastroenterologia Japonica·K HoriiT Yamamoto
Oct 1, 1987·Scandinavian Journal of Clinical and Laboratory Investigation·C H FlorénJ J Albers
Jan 1, 1983·The Journal of International Medical Research·M De MartiisF Sebastiani
Mar 24, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·B WoldsethB O Christophersen
Jan 1, 1979·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·G Nordby, B Schreiner
Jan 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·D S HarryN McIntyre
Jan 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·J P Miller
Nov 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·G NordbyK R Norum

Related Concepts

Acyltransferase
Blood
Epicholesterol
Colchicine, (R)-Isomer
Actidione
Hydrogen-Ion Concentration
Lactate Dehydrogenase
Phosphatidylcholine-Sterol O-Acyltransferase
Liver
Triglycerides

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