PMID: 7580875Aug 1, 1995Paper

Secretion of methoxyindoles from trout pineal organs in vitro: indication for a paracrine melatonin feedback

Neurochemistry International
J Yáñez, H Meissl

Abstract

Synthesis and release of the pineal hormone melatonin is in all vertebrates primarily regulated by the light/dark cycle. In pineal organs of teleost fish, like in other non-mammalian vertebrates, melatonin formation is regulated by a direct photoreception of the pineal organ. We performed measurements in explanted, perifused pineal organs of the rainbow trout, Oncorhynchus mykiss, to examine whether melatonin can influence its own production. For this purpose we have continuously perifused isolated pineal organs under light- and dark-adapted conditions and measured the release of melatonin and other methoxy-indoles by HPLC with electrochemical detection. Addition of 2-iodomelatonin to the perifusate in a concentration of 2 ng/ml significantly inhibited melatonin release in light-, as well as in dark-adapted organs. The release of 5-methoxytryptamine and 5-methoxytryptophol was also significantly reduced in light-adapted organs. These results indicate that extracellular melatonin may act as a paracrine or autocrine feedback signal and may be important for the illumination-dependent melatonin production.

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Citations

Nov 24, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M J HerreroJ A Madrid
Jul 15, 2006·Neuroscience and Behavioral Physiology·S S Pertsov
Jun 14, 2005·General and Comparative Endocrinology·Rosa M CeinosJesús M Míguez
May 25, 1999·Progress in Neurobiology·J Falcón
Apr 1, 1997·The European Journal of Neuroscience·V BollietJ Falcón
Apr 9, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·S S PertsovG V Pirogova
Dec 15, 2020·General and Comparative Endocrinology·Farha YasminSourav Mukherjee
Mar 27, 2021·Journal of Neuroendocrinology·Laura Gabriela NisembaumJack Falcón
Jan 18, 2014·The Journal of Experimental Biology·Marcos A López-PatiñoJesús M Míguez

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