PMID: 144870Oct 6, 1977

Secretion of monoquaternary ammonium compounds by guinea pig small intestine in vivo

Naunyn-Schmiedeberg's Archives of Pharmacology
K Turnheim, F O Lauterbach

Abstract

In anesthetized guinea pigs N-(3H)methylscopolamine (NMScop), N1-(14C)methylnicotinamide (NMN), and (14C)tetraethylammonium (TEA), administered intravenously, were secreted against a concentration gradient into the lumen of the small intestine. The concentration ratio of unmetabolized ammonium base in the intestinal lumen to that in the plasma was 4.3 and 6.5 for NMScop and NMN, respectively, 75 min after the intravenous injection of 1 nmole/g body weight of the individual compounds. The corresponding value for TEA after 180 min was 2.0. The establishment of the concentration gradient between intestinal lumen and plasma was diminished with increasing doses. An excess of NMN inhibited the uphill transport of NMScop. Since the electrical potential difference across the intestinal epithelium and a 'fluid circuit' mechanism cannot solely account for the observed accumulation of the monoquaternary ammonium compounds in the intestinal lumen, the evidence presented supports previous in vitro findings that the small intestine is capable of actively secreting organic cations.

References

Jan 15, 1977·Biochemical Pharmacology·K Turnheim, F O Lauterbach
Jul 1, 1966·Archives of Biochemistry and Biophysics·G P Quinn, P Greengard
Jul 1, 1971·Archives of Biochemistry and Biophysics·M Stanulović, S Chaykin
Jul 1, 1971·Archives of Biochemistry and Biophysics·M Stanulović, S Chaykin
Jan 1, 1970·Annual Review of Physiology·T R Hendrix, T M Bayless
Jul 1, 1971·British Journal of Pharmacology·G B Frank, M Ota
May 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·J P McMurtry, R R Anderson
Nov 1, 1968·The American Journal of Physiology·D W PowellG R Plotkin
May 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·T ASANO
Jan 1, 1974·Annual Review of Physiology·S G SchultzH N Nellans

Citations

Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T J Rimele, T S Gaginella
Jan 1, 1981·European Journal of Drug Metabolism and Pharmacokinetics·L AllanR F Palmer
Aug 28, 1998·The Journal of Pharmacy and Pharmacology·R SandströmH Lennernäs
May 23, 1998·Annual Review of Pharmacology and Toxicology·L ZhangK M Giacomini
Jan 1, 1989·European Journal of Clinical Pharmacology·K EnsingP J Cornelissen
Mar 1, 1987·Pharmacology & Toxicology·B Hallén, A Sundwall
Oct 15, 1984·Biochemical Pharmacology·M YasuharaH Sezaki
Mar 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A BarrowR F Palmer
Nov 1, 1978·Acta Pharmacologica Et Toxicologica·R B Sund, F O Lauterbach
Jan 1, 1985·Drug Intelligence & Clinical Pharmacy·K L Massey, V P Gotz
Oct 1, 1985·Acta Pharmacologica Et Toxicologica·B HallénS Sandquist
Jun 1, 1997·Molecular Pharmacology·L ZhangK M Giacomini
Jan 1, 1979·The American Journal of Physiology·A Hurwitz

Related Concepts

Quaternary Ammonium Compounds
Metazoa
Cavia porcellus
Intestines, Small
Enduramide
Isopto Hyoscine
In Vitro [Publication Type]

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
R H MoseleyL J Zugger
Mammalian Genome : Official Journal of the International Mammalian Genome Society
M R KoehlerM Schmid
© 2021 Meta ULC. All rights reserved