Secretion of protein from salivary glands in the ferret in response to vasoactive intestinal peptide

The Journal of Physiology
J Ekström, G Tobin

Abstract

1. Secretory responses of ferret parotid and submandibular glands were investigated in the presence of muscarinic, alpha- and beta-adrenoceptor blocking agents. 2. In pentobarbitone-anaesthetized animals I.V. doses of vasoactive intestinal peptide (VIP) failed to elicit overt secretion of saliva from either gland. 3. However, an occult secretion of protein occurred in response to VIP from both types of gland. This was revealed by means of a subsequent I.V. wash-out injection of substance P, which is a potent secretagogue in ferrets. This effect of VIP was much more marked in the submandibular than in the parotid gland. 4. Electrical stimulation of the chorda-lingual nerve gave rise to protein secretion in the submandibular gland at subthreshold frequencies for overt non-cholinergic, non-adrenergic secretion of saliva, as revealed by subsequent wash-out I.V. injection of substance P. 5. Protein secretion in response to VIP was also demonstrated in vitro by perifusing small pieces of the two glands. The sensitivity of submandibular tissue to VIP greatly exceeded that of the parotid tissue. 6. It is concluded that VIP, or a structurally related peptide, may be involved in the non-cholinergic, non-adrenergic secretory response of f...Continue Reading

Citations

Mar 1, 1995·Human Communication Research·T M Singelis, W J Brown
Mar 11, 2008·Archives of Oral Biology·Anders T RybergGunnar Tobin
Sep 28, 2004·Transcultural Psychiatry·Marwan Dwairy
Aug 11, 2007·Psychological Reports·Isabel MartínezSantiago Yubero
Apr 29, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·C M ShaariI Sanders
Dec 1, 1993·Electrophoresis·T MarshallO Vesterberg
Jul 15, 2003·Journal of Applied Physiology·C M B EdwardsA V Edwards
Jan 1, 1992·Acta Oto-laryngologica·C Hauser-KronbergerG W Hacker
Feb 24, 2001·Annals of the New York Academy of Sciences·N YanaiharaC Yanaihara
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche

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