PMID: 8939628Oct 1, 1996Paper

Secretion of recombinant proteins by Gram-negative bacteria

Current Opinion in Biotechnology
M Sandkvist, M Bagdasarian

Abstract

During the past few years, significant progress has been made towards our understanding of the molecular mechanisms governing the translocation of proteins through bacterial cell membranes. Successful attempts in promoting the secretion of recombinant proteins by employing this knowledge and by empirical efforts have been registered. However, a further in-depth understanding of membrane-translocation mechanisms is required before predictable manipulations of secretion systems can be made to secrete native recombinant proteins that are not naturally targeted to the extracellular compartment.

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Citations

Mar 6, 1998·Trends in Biotechnology·G Hannig, S C Makrides
Jun 1, 2002·Journal of Biotechnology·Patrik SamuelsonStefan Ståhl
Nov 14, 1997·Current Opinion in Biotechnology·T A Kost
May 30, 2012·Microbial Cell Factories·Yanina R SevastsyanovichIan R Henderson
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May 22, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Panos LehouritisMark Tangney
Sep 17, 2013·Biotechnology and Applied Biochemistry·Garshasb RigiKambiz Akbari Noghabi
Mar 23, 2021·Biotechnology Progress·Michael VitelliMelih Tamer
Jun 15, 2013·ACS Synthetic Biology·Saurabh GuptaRon Weiss

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