Secretion of salivary statherin is compromised in uncontrolled diabetic patients

BBA Clinical
Masahiro IzumiChih-Ko Yeh

Abstract

Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects. A total of 48 diabetic and healthy controls were randomly selected from a community-based database. Diabetic subjects (n=24) had fasting glucose levels >180 mg/dL, while controls (n=24) had levels <110 mg/dL. Parotid saliva (PS) and sublingual/submandibular saliva (SS) were collected and salivary flow rates determined. Salivary statherin levels were determined by densitometry of Western blots. Blood hemoglobin A1c (HbA1c) and total protein in saliva were also obtained. SS, but not PS, salivary flow rate and total protein in diabetics were significantly less than in healthy controls (p=0.021 & p<0.001 respectively). Correlation analysis revealed the existence of a negative correlation between PS statherin levels and HbA1c (p=0.012) and fasting glucose (p=0.021) levels, while no such correlation was found for SS statherin levels. When statherin levels were normalized to total salivary protein, the proportion of PS statherin, but not SS statherin, in diabetics was significantly less than controls (p=0.032). In contrast, the amount o...Continue Reading

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Citations

Jan 18, 2016·Archives of Oral Biology·Jitjiroj IttichaicharoenSiriporn C Chattipakorn
Mar 27, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toshiya SatoHisayoshi Ishii
Jul 28, 2020·Diagnostics·Kristina MalsagovaAnna Kaysheva
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Feb 13, 2018·Autoimmunity Reviews·Kashi Raj BhattaraiHan-Jung Chae
Jul 3, 2021·Journal of Molecular Histology·Malak FouaniAngelo Leone

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Methods Mentioned

BETA
transmission electron microscopy
ELISA
electrophoresis

Software Mentioned

PASW Statistics
Power
Scion Image

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